1. Neuronal Signaling
  2. Glucosylceramide Synthase (GCS)
  3. D-threo-PPMP


Cat. No.: HY-116535C
Handling Instructions

D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production.

For research use only. We do not sell to patients.

D-threo-PPMP Chemical Structure

D-threo-PPMP Chemical Structure

CAS No. : 139889-53-5

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Top Publications Citing Use of Products
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D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production[1][2].

IC50 & Target

glucosylceramide synthase[1]

In Vitro

D-threo-PPMP (10 μM; 72 h) decreases the MDR1 expression by 70% in KB-V0.01 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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D-threo-PPMP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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