DL-threo-PPMP hydrochloride
Based on 1 Customer Validation
DL-threo-PPMP hydrochloride is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP hydrochloride inhibits the activity of sphingosine synthetase (sphingosine synthetase) by binding to a substrate that mimics sphingosine. This inhibition leads to a rapid decline in sensitive sphingomyelin synthase (SSS) activity, selectively disrupting the interconnected tubular network of TVM in the cytoplasm of the host cell, and this inhibition also blocks the proliferation of the parasite. DL-threo-PPMP hydrochloride can be used in the study of malaria parasite biology and the search for new antimalarial strategies.
For research use only. We do not sell to patients.
- Purity : 98.05%
- CAS No.: 139974-41-7
- Formula: C29H51ClN2O3
- Molecular Weight:511.18
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-N6707
Triacsin CACSL Inhibitor -
HY-16743
IbiglustatGlucosylceramide Synthase Inhibitor -
HY-116392D
PDMP hydrochlorideGCS Inhibitor -
HY-116392B
DL-threo-PDMP hydrochlorideGlucosylceramide Synthase Inhibitor -
HY-13988
AT-56L-PGDS Inhibitor -
HY-W013665
(S)-2-Aminohexanedioic acidBiochemical Reagent -
HY-W013665R
(S)-2-Aminohexanedioic acid (Standard)Standard of (S)-2-Aminohexanedioic acid -
HY-W042985
1-BenzylimidazoleBiochemical Reagent -
HY-117769
GSK837149AFASN Inhibitor -
HY-116392F
D-threo-PDMP hydrochlorideGCS Inhibitor -
HY-121362
Evernic AcidTrxR1 Inhibitor -
HY-13988R
AT-56 (Standard)L-PGDS Inhibitor
All Parasite Isoforms
More
Biological Activity
Description
Chemical Information
-
CAS No. 139974-41-7
-
Appearance Solid
-
Molecular Weight 511.18
-
Formula C29H51ClN2O3
-
Color White to off-white
-
SMILES
O=C(N[C@@H]([C@@H](C1=CC=CC=C1)O)CN2CCOCC2)CCCCCCCCCCCCCCC.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Protocols
-
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
-
Data Sheet (262 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DL-threo-PPMP hydrochloride Related Classifications
HY-116535A Related Classifications
Powered by Bioz