C2 Adamantanyl galactosylceramide (d18:1/2:0)
C2 Adamantanyl galactosylceramide (AdaGalCer) (d18:1/2:0) is a bioactive sphingolipid. C2 Adamantanyl galactosylceramide (d18:1/2:0) stimulates glucocerebrosidase activity in vitro. C2 Adamantanyl galactosylceramide (d18:1/2:0) inhibits microsomal LacCer and Gb3 synthase, and inhibits cell sulfatide synthesis. C2 Adamantanyl galactosylceramide (d18:1/2:0) reduces glucosylceramide (GlcCer) levels in normal and lysosomal storage disease (LSD) cells. C2 Adamantanyl galactosylceramide (d18:1/2:0) acts as a substrate for A4GALT and is able to lower Gb3 levels with an IC50 concentration of 40 μM in fabry disease cells.
For research use only. We do not sell to patients.
- CAS No.: 574738-16-2
- Formula: C36H63NO8
- Molecular Weight:637.89
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
HY-113335
Trihydroxycholestanoic acid -
HY-N7745
Glucosylsphingosine -
HY-132187
Sphingosylphosphorylcholine -
HY-14113
2-Acetyl-4-tetrahydroxybutyl imidazole -
HY-148292
C16-Sphingosine-1-phosphate -
HY-116535
D-threo-PPMP hydrochloride -
HY-137422
D-erythro-MAPP -
HY-165135
Rac-Sphingosylphosphorylcholine -
HY-158940
N-Glycine 3'-sulfo galactosylsphingosine
Biological Activity
Description
Chemical Information
-
CAS No. 574738-16-2
-
Molecular Weight 637.89
-
Formula C36H63NO8
-
SMILES
OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CC23CC4CC(CC(C4)C3)C2)=O
-
Synonyms
AdaGalCer(d18:1/2:0); Admantanyl galactosylceramide (d18:1/2:0); Admantanyl galCer(d18:1/2:0)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kamani M, et al. Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism. J Biol Chem. 2011 Jun 17;286(24):21413-26. [Content Brief]
[2]. Kok K, et al. Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions. Biomolecules. 2021 Feb 12;11(2):271. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
C2 Adamantanyl galactosylceramide (d18:1/2:0) Related Classifications
HY-156208 Related Classifications
Powered by Bioz