139889-65-9
139889-65-9
Chemical Structure
D-threo-PPMP hydrochloride
- CAS No.: 139889-65-9
- Formula:C29H51ClN2O3
- Molecular Weight:511.18
IUPAC Name: N-((1R,2R)-1-hydroxy-3-morpholino-1-phenylpropan-2-yl)palmitamide hydrochloride
InChIKey: ORVAUBQYJOFWFY-ZHESDOBJSA-N
SMILES: O=C(N[C@@H]([C@@H](C1=CC=CC=C1)O)CN2CCOCC2)CCCCCCCCCCCCCCC.Cl
Biological Activity: D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].
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D-threo-PPMP hydrochloride | D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-116535ADL-threo-PPMP hydrochloride -
Similarity Score 0.99
HY-115737L-threo-PPMP -
Similarity Score 0.99
HY-116535BDL-threo-PPMP -
Similarity Score 0.99
HY-116535CD-threo-PPMP -
Similarity Score 0.89
HY-116392A(−)-L-threo-PDMP hydrochloride -
Similarity Score 0.89
HY-116392BDL-threo-PDMP hydrochloride -
Similarity Score 0.89
HY-116392FD-threo-PDMP hydrochloride -
Similarity Score 0.89
HY-116392HD,L-erythro-PDMP hydrochloride -
Similarity Score 0.88
HY-116392ED-threo-PDMP -
Explore the MedChemAI to find more analogs
References
- [1]. Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7. [Content Brief]
- [2]. Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49. [Content Brief]
