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Cat. No.: HY-116392A

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(−)-L-threo-PDMP hydrochloride

(−)-L-threo-PDMP hydrochloride is the hydrochloride form of (−)-L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells.

For research use only. We do not sell to patients.

CAS No.: 161491-04-9
Formula: C₂₃H₃₉ClN₂O₃
Molecular Weight:427.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

(−)-L-threo-PDMP hydrochloride Chemical Structure

CAS No.: 161491-04-9

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Description

Chemical Information

CAS No. 161491-04-9
Molecular Weight 427.02
Formula C₂₃H₃₉ClN₂O₃
SMILES

CCCCCCCCCC(N[C@@H](CN1CCOCC1)[C@H](C2=CC=CC=C2)O)=O.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mitchell SA, et al. Glycosyltransferase Inhibitors: Synthesis of D-threo-PDMP, L-threo-PDMP, and Other Brain Glucosylceramide Synthase Inhibitors from D-or L-Serine. The Journal of Organic Chemistry. 1998, 63(24): 8837-8842.

[2]. Chatterjee S, et al. Studies of the action of ceramide-like substances (D- and L-PDMP) on sphingolipid glycosyltransferases and purified lactosylceramide synthase. Glycoconj J. 1996 Jun;13(3):481-6. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(−)-L-threo-PDMP hydrochloride

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(−)-L-threo-PDMP hydrochloride Related Classifications

HY-116392A Related Classifications