161491-04-9
161491-04-9
Chemical Structure
(−)-L-threo-PDMP hydrochloride
- CAS No.: 161491-04-9
- Formula:C23H39ClN2O3
- Molecular Weight:427.02
IUPAC Name: N-((1S,2S)-1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide hydrochloride
InChIKey: HVJHJOYQTSEKPK-IUQUCOCYSA-N
SMILES: CCCCCCCCCC(N[C@@H](CN1CCOCC1)[C@H](C2=CC=CC=C2)O)=O.Cl
Biological Activity: (−)-L-threo-PDMP hydrochloride is the hydrochloride form of (−)-L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells[1][2].
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(−)-L-threo-PDMP hydrochloride | (−)-L-threo-PDMP hydrochloride is the hydrochloride form of (−)-L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells. | |||||||||||||||||||||
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References
- [1]. Mitchell SA, et al. Glycosyltransferase Inhibitors: Synthesis of D-threo-PDMP, L-threo-PDMP, and Other Brain Glucosylceramide Synthase Inhibitors from D-or L-Serine. The Journal of Organic Chemistry. 1998, 63(24): 8837-8842.
- [2]. Chatterjee S, et al. Studies of the action of ceramide-like substances (D- and L-PDMP) on sphingolipid glycosyltransferases and purified lactosylceramide synthase. Glycoconj J. 1996 Jun;13(3):481-6. [Content Brief]
Keywords
