D,L-erythro-PDMP
D,L-erythro-PDMP is an erythro isomer of PDMP. D,L-erythro-PDMP causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase.
For research use only. We do not sell to patients.
- CAS No.: 109760-77-2
- Formula: C23H38N2O3
- Molecular Weight:390.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
D,L-erythro-PDMP (0, 12, 25, 50 μM; 0, 4, 7, 10 days) shows an inhibitory effect on cell growth of rabbit skin fibroblasts[1].
D,L-erythro PDMP (50 μM; 3 days) has cytotoxic of rabbit skin fibroblasts on cell morphology[1].
D,L-erythro-PDMP (40 μM; 24 h; MDCK cells) induces a marked increase in glucosyltransferase specific activity: 14.6 nmol/h per mg protein[2].
D,L-erythro-PDMP (40 μM; 6 h) protects the cells against loss of synthase in cells exposed to cycloheximide[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rabbit skin fibroblast
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Concentration:0, 12, 25, 50 μM
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Incubation Time:0, 4, 7, 10 days
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Result:Showed an inhibitory effect on cell growth.
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Cell Line:Rabbit skin fibroblast
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Concentration:50 μM
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Incubation Time:3 days
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Result:Had cytotoxic on cell morphology.
Chemical Information
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CAS No. 109760-77-2
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Molecular Weight 390.56
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Formula C23H38N2O3
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SMILES
O[C@@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108(4):525-30. [Content Brief]
[2]. Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D,L-erythro-PDMP Related Classifications
HY-116392G Related Classifications
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