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D,L-erythro-PDMP 

Cat. No.: HY-116392G
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D,L-erythro-PDMP is an erythro isomer of PDMP. D,L-erythro-PDMP causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase.

For research use only. We do not sell to patients.

D,L-erythro-PDMP Chemical Structure

D,L-erythro-PDMP Chemical Structure

CAS No. : 109760-77-2

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Description

D,L-erythro-PDMP is an erythro isomer of PDMP. D,L-erythro-PDMP causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].

In Vitro

D,L-erythro-PDMP (0, 12, 25, 50 μM; 0, 4, 7, 10 days) shows an inhibitory effect on cell growth of rabbit skin fibroblasts[1].
D,L-erythro PDMP (50 μM; 3 days) has cytotoxic of rabbit skin fibroblasts on cell morphology[1].
D,L-erythro-PDMP (40 μM; 24 h; MDCK cells) induces a marked increase in glucosyltransferase specific activity: 14.6 nmol/h per mg protein[2].
D,L-erythro-PDMP (40 μM; 6 h) protects the cells against loss of synthase in cells exposed to cycloheximide[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Rabbit skin fibroblast
Concentration: 0, 12, 25, 50 μM
Incubation Time: 0, 4, 7, 10 days
Result: Showed an inhibitory effect on cell growth.

Cell Cytotoxicity Assay[1]

Cell Line: Rabbit skin fibroblast
Concentration: 50 μM
Incubation Time: 3 days
Result: Had cytotoxic on cell morphology.
Molecular Weight

390.56

Formula

C₂₃H₃₈N₂O₃

CAS No.
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D,L-erythro-PDMP
Cat. No.:
HY-116392G
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