2. Others Metabolic Enzyme/Protease Apoptosis
  3. Biochemical Assay Reagents Aminotransferases (Transaminases) Environmental Pollutants Phosphatase Apoptosis
  4. Diethyl phthalate

Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility.

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Diethyl phthalate

Diethyl phthalate Chemical Structure

CAS No. : 84-66-2

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
Liquid
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1 kg In-stock

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Based on 2 publication(s) in Google Scholar

Other Forms of Diethyl phthalate:

Diethyl phthalate Related Antibodies

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Description

Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility[1][2].

In Vivo

Diethyl phthalate (25-100 ppm; continuous/daily single aquatic exposure; 3 days-72 h) causes dose-dependent mortality in the fish species *Cirrhina mrigala*, with 100% mortality observed within 24 h at concentrations of 75 ppm and 100 ppm; exposure at 25 ppm also alters the activities of key metabolic and neurological enzymes[1].
Diethyl phthalate (p.o.) mainly distributes in the kidneys and liver of rats, and subsequently accumulates in adipose tissue[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cirrhina mrigala (65 mm length, 4 g weight, 6 fish per group)[1]
Dosage: 25 ppm, 50 ppm, 75 ppm, 100 ppm (mortality assessment); 25 ppm (enzyme activity assays)
Administration: aquatic exposure; continuous (mortality assessment); once daily; 3 days (enzyme activity assays)
Result: Caused 100% mortality within 24 hours in fish exposed to 75 ppm and 100 ppm DEP.
Caused 50% mortality within 72 hours in fish exposed to 50 ppm DEP.
Caused 10% mortality within 72 hours in fish exposed to 25 ppm DEP, with remaining fish surviving the extended 3-day treatment.
Significantly increased liver and muscle acid phosphatase (ACP) and alkaline phosphatase (ALP) activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Significantly increased muscle succinate dehydrogenase (SDH) activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Significantly increased liver alanine aminotransferase (ALT) activity (nearly double) compared to controls in fish treated with 25 ppm DEP for 3 days.
Significantly decreased brain acetylcholinesterase (AchE) activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Significantly increased liver aspartate aminotransferase (AST) activity compared to negative controls (though lower than positive controls) in fish treated with 25 ppm DEP for 3 days.
Showed no significant change in liver SDH activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Showed no significant change in muscle AchE activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Molecular Weight

222.24

Formula

C12H14O4
CAS No.
Appearance

Liquid (Density: 1.12 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(C1=CC=CC=C1C(OCC)=O)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (899.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4996 mL 22.4982 mL 44.9964 mL
5 mM 0.8999 mL 4.4996 mL 8.9993 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.87%

SDS (762 KB)

COA (253 KB) HNMR (112 KB) RP-HPLC (339 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4996 mL 22.4982 mL 44.9964 mL 112.4910 mL
5 mM 0.8999 mL 4.4996 mL 8.9993 mL 22.4982 mL
10 mM 0.4500 mL 2.2498 mL 4.4996 mL 11.2491 mL
15 mM 0.3000 mL 1.4999 mL 2.9998 mL 7.4994 mL
20 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
25 mM 0.1800 mL 0.8999 mL 1.7999 mL 4.4996 mL
30 mM 0.1500 mL 0.7499 mL 1.4999 mL 3.7497 mL
40 mM 0.1125 mL 0.5625 mL 1.1249 mL 2.8123 mL
50 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
60 mM 0.0750 mL 0.3750 mL 0.7499 mL 1.8748 mL
80 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4061 mL
100 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL
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Diethyl phthalate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diethyl phthalate84-66-2Biochemical Assay ReagentsAminotransferases (Transaminases)Environmental PollutantsPhosphataseApoptosisAminotransferases (Transaminases) Environmental ContaminantsCirrhina mrigalasuccinate dehydrogenasebrainacetylcholinesteraseliverratsaspartate aminotransferasealkaline phosphatasealanine aminotransferaseacid phosphataseInhibitorinhibitorinhibit

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