2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE5-IN-16

PDE5-IN-16 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 0.8 nM. PDE5-IN-16 enhances the relaxation of corpus cavernosum tissue strips. PDE5-IN-16 is applicable for the research of erectile dysfunction.

For research use only. We do not sell to patients.

PDE5-IN-16

PDE5-IN-16 Chemical Structure

CAS No. : 261769-44-2

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PDE5-IN-16 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

PDE5-IN-16 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 0.8 nM. PDE5-IN-16 enhances the relaxation of corpus cavernosum tissue strips. PDE5-IN-16 is applicable for the research of erectile dysfunction[1].

In Vitro

PDE5-IN-16 (Compound 5) potently inhibits human platelet PDE5 with an IC50 of 0.8 nM and exhibits high selectivity over bovine heart PDE1, rat kidney PDE2, human platelet PDE3, rat kidney PDE4, and bovine retina PDE6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE5-IN-16 Related Antibodies
Parmacokinetics
Species Dose Route Bioavailability T1/2
Rat[1] 21 μmol/Kg p.o. 33 % 1.2 h
Dog[1] 23 μmol/Kg p.o. 66 % 2.3 h
In Vivo

PDE5-IN-16 (Compound 5) (10-250 mg/kg; p.o.) shows no drug-related adverse effects in Rattus norvegicus at oral doses up to 50 mg/kg, with only mild body weight reduction in male rats at 250 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

450.93

Formula

C23H23ClN6O2
CAS No.
SMILES

O=C(NCC=1C=CN=CC1)C2=CN=C3C(C=NN3CC)=C2NCC4=CC=C(OC)C(Cl)=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PDE5-IN-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE5-IN-16261769-44-2Phosphodiesterase (PDE)PDE5dogsPDE1corpus cavernosal tissue stripserectile dysfunctionbovine heartPDE6phosphodiesterase type 5human plateletratsInhibitorinhibitorinhibit

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