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Cat. No.: HY-114797

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PDE5-IN-16

PDE5-IN-16 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ of 0.8 nM. PDE5-IN-16 enhances the relaxation of corpus cavernosum tissue strips. PDE5-IN-16 is applicable for the research of erectile dysfunction.

For research use only. We do not sell to patients.

CAS No.: 261769-44-2
Formula: C₂₃H₂₃ClN₆O₂
Molecular Weight:450.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE5-IN-16 Chemical Structure

CAS No.: 261769-44-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Phosphodiesterase (PDE) Isoforms :

In Vitro

PDE5-IN-16 (Compound 5) potently inhibits human platelet PDE5 with an IC₅₀ of 0.8 nM and exhibits high selectivity over bovine heart PDE1, rat kidney PDE2, human platelet PDE3, rat kidney PDE4, and bovine retina PDE6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Parmacokinetics

Species	Dose	Route	Bioavailability	T_1/2
Rat^[1]	21 μmol/Kg	p.o.	33 %	1.2 h
Dog^[1]	23 μmol/Kg	p.o.	66 %	2.3 h

In Vivo

PDE5-IN-16 (Compound 5) (10-250 mg/kg; p.o.) shows no drug-related adverse effects in Rattus norvegicus at oral doses up to 50 mg/kg, with only mild body weight reduction in male rats at 250 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 261769-44-2
Molecular Weight 450.93
Formula C₂₃H₂₃ClN₆O₂
SMILES

O=C(NCC=1C=CN=CC1)C2=CN=C3C(C=NN3CC)=C2NCC4=CC=C(OC)C(Cl)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yu G, et al. Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2001 Mar 29;44(7):1025-7.
[Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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