Perfluorotetradecanoic acid  (Synonyms: PFTeDA)

Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a K_d value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the SIRT1/PGC1α and AMPK signaling pathways while stimulating the activity of the AKT1/mTOR signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats^[1][3][2].

Perfluorotetradecanoic acid (1-50 μM; 24 h) significantly inhibits testosterone secretion in primary rat Leydig cells^[1].
Perfluorotetradecanoic acid (10-50 μM; 24 h) significantly increases the level of ROS in primary rat Leydig cells, with a stronger effect observed at 50 μM^[1].
Perfluorotetradecanoic acid (50 μM; 24 h) significantly increases the apoptosis rate of primary rat Leydig cells^[1].
Perfluorotetradecanoic acid directly binds to the purified ligand-binding domain of hPPARγ, with a K_d value of 157.8 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Perfluorotetradecanoic acid (1-10 mg/kg/day; i.g.; daily; 28 days) disrupts Leydig cell function and male reproductive endocrine function in adult male rats at doses ≥1 mg/kg/day, reducing serum testosterone by ≥50% at 1 mg/kg/day, increasing oxidative stress, and inducing apoptosis of Leydig and germ cells^[1].
Perfluorotetradecanoic acid (1-10 mg/kg; i.g.; daily; 28 days) disrupts adrenal cortex function in adult male rats, with the 10 mg/kg dose driving the most robust effects: increased corticosterone biosynthesis via zona fasciculata hyperplasia and upregulated steroidogenic gene/protein expression, decreased aldosterone biosynthesis via downregulated Cyp11b2 expression, impaired antioxidant defense, and altered SIRT1/PGC1α, AMPK, and AKT1/mTOR signaling^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

714.11

C₁₄HF₂₇O₂

376-06-7

Solid

White to off-white

O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)F)F)F)F)F)O

Room temperature in continental US; may vary elsewhere.

• [1]. Tang Y, et al. Leydig cell function in adult male rats is disrupted by perfluorotetradecanoic acid through increasing oxidative stress and apoptosis. Environ Toxicol. 2022;37(7):1790-1802.  [Content Brief]

  [2]. Zhang L, et al. Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ. Toxicol Appl Pharmacol. 2014;279(3):275-283.  [Content Brief]

  [3]. Ying Y, et al. Perfluorotetradecanoic acid exposure to adult male rats stimulates corticosterone biosynthesis but inhibits aldosterone production. Environ Toxicol. 2024;39(5):2610-2622.  [Content Brief]