2. Anti-infection
  3. Parasite
  4. Trypaflavin bromide

Trypaflavin bromide is an orally active acridine compound and antimalarial agent. Trypaflavin bromide invades germ cells. Trypaflavin bromide induces aberrations in unfertilized oocytes. Trypaflavin bromide increases the frequency of chromosomal aberrations. Trypaflavin bromide shows weak mutagenicity. Trypaflavin bromide is highly toxic to Leishmania, causing immediate lysis of the leptomonads.

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Trypaflavin bromide

Trypaflavin bromide Chemical Structure

CAS No. : 857613-80-0

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Description

Trypaflavin bromide is an orally active acridine compound and antimalarial agent. Trypaflavin bromide invades germ cells. Trypaflavin bromide induces aberrations in unfertilized oocytes. Trypaflavin bromide increases the frequency of chromosomal aberrations. Trypaflavin bromide shows weak mutagenicity. Trypaflavin bromide is highly toxic to Leishmania, causing immediate lysis of the leptomonads[1][2].

In Vivo

Trypaflavin (50 mg/kg; p.o.; single acute dose; day 7 post conception) bromide induces dominant lethal mutations in F1 female offspring of pregnant C3H mice, with an induced mutation frequency of 13.25[1].
Trypaflavin (2 mg/kg/day; p.o.; 50 days) bromide slightly elevates preimplantation egg loss and dead implants without inducing significant dominant lethal mutations in female C3H mice, and weakly increases total chromosome aberration frequencies to 21.1% in metaphase-II oocytes of female NMRI mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H (female; parental generation; pregnant; prenatal in utero treatment to target oogonia/early meiotic oocyte stages); C3H F1 (female; 10 weeks old at mating)[1]
Dosage: 50 mg/kg
Administration: p.o.; single acute dose; day 7, 11, 14, or 15 post conception
Result: Induced significant mutagenic effects only with day 7 post conception treatment: Increased preimplantation egg loss to 24.9%.
Increased dead implants per female to 1.4.
Decreased living embryos per female to 7.2.
Induced dominant lethal mutations of 13.25.
Showed no significant effects with treatment on days 11, 14, or 15 post conception.
Animal Model: C3H (female; 3 weeks old at study start)[1]
Dosage: 2 mg/kg/day
Administration: p.o.; daily; 50 days
Result: Increased preimplantation egg loss to 13.3%.
Increased dead implants per female to 2.2.
Induced dominant lethal mutations of -1.27.
Animal Model: NMRI (female; 3 weeks old at study start)[1]
Dosage: 2 mg/kg/day
Administration: p.o.; daily; at least 50 days
Result: Increased the frequency of aberrant metaphase-II oocytes to 21.1%, aneuploidies to 13.5%, structural aberrations including gaps to 9.3%, and structural aberrations excluding gaps to 8.1%.
Increased yield of all aberration types (aneuploidies, gaps, breaks and fragments, satellite associations, deletions, interchanges).
Molecular Weight

304.19

Formula

C14H14BrN3
CAS No.
Appearance

Solid

Color

Orange to reddish brown

SMILES

NC1=CC=C2C=C3C=CC(N)=CC3=[N+](C)C2=C1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Trypaflavin bromide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypaflavin857613-80-0 Parasitepregnant miceC3H miceLeishmania tropicaaneuploidiesmetaphase-II oocyte chromosomesmale mouse germ cellsBaghdad boilfibroblastNMRI miceleptomonadsInhibitorinhibitorinhibit

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