Trypaflavin bromide
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Trypaflavin bromide is an orally active acridine compound and antimalarial agent. Trypaflavin bromide invades germ cells. Trypaflavin bromide induces aberrations in unfertilized oocytes. Trypaflavin bromide increases the frequency of chromosomal aberrations. Trypaflavin bromide shows weak mutagenicity. Trypaflavin bromide is highly toxic to Leishmania, causing immediate lysis of the leptomonads.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 97.27%
- CAS 番号: 857613-80-0
- 分子式: C14H14BrN3
- 分子量:304.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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生物活性
製品説明
体内実験
Trypaflavin (2 mg/kg/day; p.o.; 50 days) bromide slightly elevates preimplantation egg loss and dead implants without inducing significant dominant lethal mutations in female C3H mice, and weakly increases total chromosome aberration frequencies to 21.1% in metaphase-II oocytes of female NMRI mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C3H (female; parental generation; pregnant; prenatal in utero treatment to target oogonia/early meiotic oocyte stages); C3H F1 (female; 10 weeks old at mating)[1]
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Dosage:50 mg/kg
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Administration:p.o.; single acute dose; day 7, 11, 14, or 15 post conception
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Result:Induced significant mutagenic effects only with day 7 post conception treatment: Increased preimplantation egg loss to 24.9%.
Increased dead implants per female to 1.4.
Decreased living embryos per female to 7.2.
Induced dominant lethal mutations of 13.25.
Showed no significant effects with treatment on days 11, 14, or 15 post conception.
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Animal Model:C3H (female; 3 weeks old at study start)[1]
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Dosage:2 mg/kg/day
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Administration:p.o.; daily; 50 days
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Result:Increased preimplantation egg loss to 13.3%.
Increased dead implants per female to 2.2.
Induced dominant lethal mutations of -1.27.
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Animal Model:NMRI (female; 3 weeks old at study start)[1]
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Dosage:2 mg/kg/day
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Administration:p.o.; daily; at least 50 days
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Result:Increased the frequency of aberrant metaphase-II oocytes to 21.1%, aneuploidies to 13.5%, structural aberrations including gaps to 9.3%, and structural aberrations excluding gaps to 8.1%.
Increased yield of all aberration types (aneuploidies, gaps, breaks and fragments, satellite associations, deletions, interchanges).
化学情報
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CAS 番号 857613-80-0
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性状 Solid
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分子量 304.19
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分子式 C14H14BrN3
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Color Orange to reddish brown
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SMILES
NC1=CC=C2C=C3C=CC(N)=CC3=[N+](C)C2=C1.[Br-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Trypaflavin bromide 関連分類
HY-B1509B 関連分類
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