1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

Oltipraz (Synonyms: RP 35972; NSC 347901)

Cat. No.: HY-12519 Purity: 99.15%
Handling Instructions

Oltipraz has an inhibitory effect on HIF-1α activation by insulin in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM.

For research use only. We do not sell to patients.

Oltipraz Chemical Structure

Oltipraz Chemical Structure

CAS No. : 64224-21-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
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10 mg USD 60 In-stock
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Estimated Time of Arrival: December 31
50 mg USD 108 In-stock
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Estimated Time of Arrival: December 31
100 mg USD 168 In-stock
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Estimated Time of Arrival: December 31
200 mg USD 216 In-stock
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Estimated Time of Arrival: December 31
500 mg USD 312 In-stock
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Estimated Time of Arrival: December 31
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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Oltipraz has an inhibitory effect on HIF-1α activation by insulin in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. IC50 value: 10 μM Target: HIF-1α in vitro: Oltipraz inhibits HIF-1α activity and HIF-1α-dependent tumor growth, which may result from a decrease in HIF-1α stability through S6K1 inhibition in combination with an H2O2-scavenging effect. Oltipraz treatment also inhibits HIF-1α activation stimulated by either hypoxia or CoCl2. Oltipraz is a cancer chemopreventive agent and has an inhibitory effect on angiogenesis and tumor growth. [1] Oltipraz is also a competitive inhibitor of this cytochrome P450, with an apparent Ki of 10 μM. [2] in vivo: In wild-type mice, hepatic levels of mRNA for all of the genes analyzed were significantly increased after Oltipraz treatment, with the highest increase (treated/control) for NQO1 mRNA levels (7.6-fold). The Northern blot analyses demonstrated that the observed increases in GST and NQO1 activities by Oltipraz in wild-type mice were preceded by significant elevations in RNA expression. Interestingly, mRNA levels of Nrf2 itself were increased more than 3-fold by Oltipraz treatment. [2]

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (26.51 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4181 mL 22.0907 mL 44.1813 mL
5 mM 0.8836 mL 4.4181 mL 8.8363 mL
10 mM 0.4418 mL 2.2091 mL 4.4181 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Oltipraz is prepared in coin oil[3].

References
Molecular Weight

226.34

Formula

C₈H₆N₂S₃

CAS No.

64224-21-1

SMILES

S=C1SSC(C2=NC=CN=C2)=C1C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Oltipraz
Cat. No.:
HY-12519
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Oltipraz

Cat. No.: HY-12519