LIFR - LIF receptor subunit alpha Gene

Homo sapiens

Also known as SWS; SJS2; STWS; CD118; LIF-R

Gene ID: 3977 | Gene type: protein coding

About LIFR

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:38,474,668-38,608,403 (from NCBI)

This gene has 9 transcripts (splice variants), 193 orthologues, 23 paralogues and is associated with 86 phenotypes. Ubiquitous expression in fat (RPKM 34.2), endometrium (RPKM 21.9) and 24 other tissues.

Summary

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the Leukemia Inhibitory Factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2018]

LIFR Products(4)

mRNA	Protein	Name
NM_001127671.2	NP_001121143.1	leukemia inhibitory factor receptor isoform a precursor
NM_001364297.2	NP_001351226.1	leukemia inhibitory factor receptor isoform a precursor
NM_001364298.2	NP_001351227.1	leukemia inhibitory factor receptor isoform b precursor
NM_002310.6	NP_002301.1	leukemia inhibitory factor receptor isoform a precursor

LIFR Protein Structure

fn3

0
200
400
600
800
1000
1097 a.a.

Protein Preferred Names

Protein Names

leukemia inhibitory factor receptor

CD118 antigen

Recombinant LIFR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77058	LIFR Protein, Human (HEK293, Fc)	P42702 (M1-S833)	≥95%
HY-P77059	LIFR Protein, Human (HEK293, His)	P42702 (M1-S833)	≥95%
HY-P77060	LIFR Protein, Human (Biotinylated, HEK293, His)	P42702 (M1-S833)	≥95%
HY-P700418	LIFR Protein, Human (HEK293, hFc-Flag)	P42702 (Q45-S833)	≥95%

Related Diseases

Diseases

Alias

Stuve-Wiedemann Syndrome 1

Stuve-Wiedemann Syndrome	Sjs2
STWS	Stuve-Wiedemann/Schwartz-Jampel Type 2 Syndrome
Sws	Schwartz-Jampel Syndrome Type 2
Stuve-Wiedemann Dysplasia	Schwartz-Jampel Syndrome, Neonatal
Stuve-Wiedemann Syndrome/Schwartz-Jampel Type 2 Syndrome	Neonatal Schwartz-Jampel Syndrome
Stüve-Wiedemann Syndrome 1	STWS1
Schwartz-Jampel Syndrome, Type 2	Neonatal Schwartz-Jampel Syndrome Type 2
Schwartz-Jampel Syndrome Neonatal	Stüve-Wiedemann Syndrome
Schwartz-Jampel Type 2 Syndrome

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Hemophagocytic Lymphohistiocytosis, Familial, 2

Familial Hemophagocytic Lymphohistiocytosis 2	FHL2
Hplh2	Hlh2
Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To	Lymphohistiocytosis, Hemophagocytic, Familial, Type 2

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Cold-Induced Sweating Syndrome

Crisponi Syndrome	Sohar-Crisponi Syndrome
Ciss	Cntf Receptor-Related Disorders
Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death	Sweating Syndrome, Cold-Induced

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Crisponi/Cold-Induced Sweating Syndrome 2

Cold-Induced Sweating Syndrome 2	CISS2
Sweating Syndrome, Cold-Induced, Type 2

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Infertility

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120142	EC359	Inducer	98.11%	Unkown
HY-RS07641	LIFR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LIFR	VGNC	VGNC:68045
Bos taurus	LIFR	VGNC	VGNC:30881
Macaca mulatta	LIFR	VGNC	VGNC:74264
Rattus norvegicus	LIFR	RGD	RGD:621431
Canis familiaris	LIFR	VGNC	VGNC:42672
Mus musculus	LIFR	MGD	MGI:96788
Others	LIFR	NCBI

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