LIFR Antibody
(Synonyms: CD118, Leukemia inhibitory factor receptor, LIF receptor, LIF-R, LIFR)LIFR Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to LIFR.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
LIFR Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to LIFR.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 124 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 123 kDa
Synthetic peptide corresponding to the C-terminal region of human LIFR.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LIFR functions as a membrane-bound signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR. Signal transmission is initiated either by binding directly to cytokines, such as OSM or LIF or CTF1, or through the binding of other cytokines, like CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor CNTFR; ligand binding induces heterodimerization of IL6ST/gp130 and LIFR which activates JAK tyrosine kinases bound to their intracellular domains. These kinases subsequently phosphorylate the homodimer or heterodimer form of IL6ST/gp130. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STATs). Engages sites 3 of ligands cytokines[1][2][3][4][5][6][7][8].
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Subcellular Localization
Cell membrane
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Isoforms & Post-Translational Modification
LIFR has 2 isoforms, P42702-1: amino acid length is 1097, molecular weight is 123743 Da (predicted); P42702-2: amino acid length is ?, molecular weight is ? Da Da (predicted).
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Subunit
Heterodimer composed of LIFR and IL6ST.
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SwissProt ID
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Synonyms
CD118, Leukemia inhibitory factor receptor, LIF receptor, LIF-R, LIFR
Documentation
[1]. Plun-Favreau H, et al. The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. EMBO J. 2001 Apr 2;20(7):1692-703. [Content Brief]
[2]. Lelièvre E, et al. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. J Biol Chem. 2001 Jun 22;276(25):22476-84. [Content Brief]
[3]. Gearing DP, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992 Mar 13;255(5050):1434-7. [Content Brief]
[4]. Zhou Y, et al. Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes. Nat Commun. 2024 Nov 12;15(1):9776. [Content Brief]
[5]. Robledo O, et al. Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component. J Biol Chem. 1997 Feb 21;272(8):4855-63. [Content Brief]
[6]. Auguste P, et al. Signaling of type II oncostatin M receptor. J Biol Chem. 1997 Jun 20;272(25):15760-4. [Content Brief]
[7]. Gearing DP, et al. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48. [Content Brief]
[8]. Zhou Y, et al. Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv. 2023 Mar 15;9(11):eade4395. [Content Brief]
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