(R)-Ofloxacin
Based on 2 publication(s) in Google Scholar
(R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria.
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- Purity: 99.82%
- CAS No.: 100986-86-5
- 화학식: C18H20FN3O4
- 분자량:361.37
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (R)-Ofloxacin
MoreAll Antibiotic Isoforms
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Biological Activity
(R)-Ofloxacin is a mixture component of Ofloxacin. In the experiment of black-spotted frog (Rana nigromaculata) tadpoles, Ofloxacin (1 μg/L; 75 days) and Levofloxacin (HY-B0330) together led to the inhibition of body weight and length growth, vacuolation of liver tissue, nuclear condensation and other pathological damage, and interfered with the expression of lipid metabolism-related proteins (such as FAS, ACC, HSL) and the level of glycerophospholipid metabolites, and had a significant effect on the expression of immune-related genes[1].
The antibacterial activity of (R)-Ofloxacin is lower than that of its L-isomer Levofloxacin (HY-B0330)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 100986-86-5
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Appearance Solid
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분자량 361.37
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화학식 C18H20FN3O4
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Color Off-white to light yellow
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SMILES
O=C(C(C1=O)=CN2[C@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O
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Synonyms
Dextrofloxacin
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Biosensors (Basel)
Double Lateral Flow Test System for Simultaneous Immunodetection of Enantiomeric Forms of Antibiotics: An Ofloxacin Case Study. [Abstract]2025 Nov 21;15(12):765. PMID: 41440246 -
Mikrochim Acta
Discrimination of the S-isomer of ofloxacin using nanozyme-enhanced immunochromatographic analysis based on a secondary antibody-modified Au@Pd nanozyme. [Abstract]2026 Jun 8;193(7):460. PMID: 42258022
용액&용해도
DMSO : 2.86 mg/mL (7.91 mM; ultrasonic and warming and adjust pH to 2 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7672 mL | 13.8362 mL | 27.6725 mL | 69.1812 mL |
| 5 mM | 0.5534 mL | 2.7672 mL | 5.5345 mL | 13.8362 mL |
(R)-Ofloxacin Related Classifications
HY-B0330D Related Classifications
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