100986-86-5
Chemical Structure
(R)-Ofloxacin
Synonym(s): Dextrofloxacin
- CAS No.: 100986-86-5
- Formula:C18H20FN3O4
- Molecular Weight:361.37
IUPAC Name: (R)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
InChIKey: GSDSWSVVBLHKDQ-SNVBAGLBSA-N
SMILES: O=C(C(C1=O)=CN2[C@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O
Biological Activity: (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria[1][2].
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(R)-Ofloxacin | 99.82% | (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria. | ||||||||||||||||||||
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(R)-Ofloxacin (Standard) | ≥98% | (R)-Ofloxacin (Standard) is the analytical standard of (R)-Ofloxacin (HY-B0330D). (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria. | ||||||||||||||||||||
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(R)-Ofloxacin-d3 | (R)-Ofloxacin-d3 is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria. | |||||||||||||||||||||
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References
- [1]. Zhang, et al. Stereoselective effects and its potential mechanism of ofloxacin on the growth and development of Rana nigromaculata: mainly liver lipid metabolism. Frontiers of Environmental Science & Engineering 19.4 (2025): 50.
- [2]. Nahla N. Salama, et al. Thin-Layer Chromatographic Enantioseparation of Ofloxacin and Zopiclone using Hydroxy-Propyl-BetaCyclodextrin as Chiral Selector and Thermodynamic Studies of Complexation. Journal of Planar Chromatography. 27 (2014) 3, 166-173.
