2. Apoptosis Cell Cycle/DNA Damage Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Cuproptosis Apoptosis Topoisomerase Reactive Oxygen Species (ROS)
  4. Cu(II)-Elesclomol

Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer.

For research use only. We do not sell to patients.

CAS No. : 1224195-72-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 5 publication(s) in Google Scholar

Cu(II)-Elesclomol Related Antibodies

Top Publications Citing Use of Products
WB
Cell Proliferation/Viability Assay
Cell Imaging/Staining
Cell Migration/Invasion Assay
Flow Cytometry

    Cu(II)-Elesclomol purchased from MedChemExpress. Usage Cited in: RSC Adv. 2025 Dec 12;15(57):49643-49651.  [Abstract]

    Expression of ATP7B under ZnO nanoparticles, ES (Cu(II)-Elesclomol: 10 μM), and ZnO nanoparticles + ES treatment.

    Cu(II)-Elesclomol purchased from MedChemExpress. Usage Cited in: RSC Adv. 2025 Dec 12;15(57):49643-49651.  [Abstract]

    Effects of ES (Cu(II)-Elesclomol: 10 μM) on intracellular ROS levels.

    Cu(II)-Elesclomol purchased from MedChemExpress. Usage Cited in: RSC Adv. 2025 Dec 12;15(57):49643-49651.  [Abstract]

    Effects of ES (Cu(II)-Elesclomol: 10 μM) on tumor cell invasion.

    Cu(II)-Elesclomol purchased from MedChemExpress. Usage Cited in: RSC Adv. 2025 Dec 12;15(57):49643-49651.  [Abstract]

    Flow cytometry was used to analyze the apoptosis of tumor cells treated with ZnO NPs, ZnO@DNAzyme, ES (Cu(II)-Elesclomol: 10 μM), ZnO NPs + ES, ZnO@DE, and ZnO@DE(M).

    Cu(II)-Elesclomol purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 Oct:503:117496.  [Abstract]

    Effects of copper ion carrier ES-Cu (Cu(II)-Elesclomol) on cell viability.

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    Topoisomerase Topo I Topo II DNA gyrase

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer[1][2].

    In Vitro

    Cu(II)-Elesclomol (0.001-50 μM; 0-80 h) inhibits the growth of K562 cells (IC50: 7.5 nM), and induces apoptosis, G1 phase cell cycle arrest and DNA double-strand breaks[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cu(II)-Elesclomol Related Antibodies

    Cell Viability Assay[1]

    Cell Line: K562 cells
    Concentration: 0.1, 1, 10, 100 and 200 nM
    Incubation Time: 0, 20, 40, 60 and 80 h
    Result: Inhibited the cell viability.
    Molecular Weight

    462.05

    Formula

    C19H18CuN4O2S2
    CAS No.
    Appearance

    Solid

    Color

    Brown to reddish brown

    SMILES

    CN1[N-](C(C2)=O)[Cu+2]([S]=C3C4=CC=CC=C4)([S]=C1C5=CC=CC=C5)[N-](C2=O)N3C
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 6.67 mg/mL (14.44 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1643 mL 10.8213 mL 21.6427 mL
    5 mM 0.4329 mL 2.1643 mL 4.3285 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 0.67 mg/mL (1.45 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 0.67 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (6.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 0.67 mg/mL (1.45 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (6.7 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1643 mL 10.8213 mL 21.6427 mL 54.1067 mL
    5 mM 0.4329 mL 2.1643 mL 4.3285 mL 10.8213 mL
    10 mM 0.2164 mL 1.0821 mL 2.1643 mL 5.4107 mL
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    Cu(II)-Elesclomol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cu(II)-Elesclomol1224195-72-5CuproptosisApoptosisTopoisomeraseReactive Oxygen Species (ROS)G1DNA double strandanticancerK562 cellsInhibitorinhibitorinhibit

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