2. Apoptosis Cell Cycle/DNA Damage
  3. Cuproptosis Apoptosis Topoisomerase
  4. Cu(II)-Elesclomol

Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity.

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Cu(II)-Elesclomol Chemical Structure

Cu(II)-Elesclomol Chemical Structure

CAS No. : 1224195-72-5

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Cu(II)-Elesclomol Related Antibodies

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Description

Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity[1].

Molecular Weight

462.05

Formula

C19H18CuN4O2S2
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

CN1[N-](C(C2)=O)[Cu+2]([S]=C3C4=CC=CC=C4)([S]=C1C5=CC=CC=C5)[N-](C2=O)N3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (14.44 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1643 mL 10.8213 mL 21.6427 mL
5 mM 0.4329 mL 2.1643 mL 4.3285 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1643 mL 10.8213 mL 21.6427 mL 54.1067 mL
5 mM 0.4329 mL 2.1643 mL 4.3285 mL 10.8213 mL
10 mM 0.2164 mL 1.0821 mL 2.1643 mL 5.4107 mL
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Cu(II)-Elesclomol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cu(II)-Elesclomol1224195-72-5CuproptosisApoptosisTopoisomeraseG1DNA double strandanticancerInhibitorinhibitorinhibit

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