MC-Gly-Gly-Phe-Gly-GABA-Exatecan
Based on 1 Customer Validation
MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo.
For research use only. We do not sell to patients.
- Purity : 99.72%
- CAS No.: 1599439-52-7
- Formula: C53H58FN9O12
- Molecular Weight:1032.08
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Camptothecins |
In Vitro
MC-Gly-Gly-Phe-Gly-GABA-Exatecan (0-10 μM) exhibits cytotoxicity in cells SR (CD30 positive), HL60 (CD33 positive), U251 (CD70 positive) and Calu-6 (B7-H3 positive) through functions with CD30, CD33, CD70 and B7-H3[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SR, HL60, U251 and Calu-6
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Concentration:0-10 μM
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Incubation Time:6 days
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Result:Reduced cell viability.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A375 xenograft mice[2]
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Dosage:10 mg/kg
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Administration:i.v, once a week for 2 weeks
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Result:Inhibited tumor growth and induced tumor regression.
Chemical Information
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CAS No. 1599439-52-7
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Appearance Solid
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Molecular Weight 1032.08
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Formula C53H58FN9O12
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Color Light yellow to yellow
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SMILES
O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCCCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (96.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9689 mL | 4.8446 mL | 9.6892 mL | 24.2229 mL |
| 5 mM | 0.1938 mL | 0.9689 mL | 1.9378 mL | 4.8446 mL | |
| 10 mM | 0.0969 mL | 0.4845 mL | 0.9689 mL | 2.4223 mL | |
| 15 mM | 0.0646 mL | 0.3230 mL | 0.6459 mL | 1.6149 mL | |
| 20 mM | 0.0484 mL | 0.2422 mL | 0.4845 mL | 1.2111 mL | |
| 25 mM | 0.0388 mL | 0.1938 mL | 0.3876 mL | 0.9689 mL | |
| 30 mM | 0.0323 mL | 0.1615 mL | 0.3230 mL | 0.8074 mL | |
| 40 mM | 0.0242 mL | 0.1211 mL | 0.2422 mL | 0.6056 mL | |
| 50 mM | 0.0194 mL | 0.0969 mL | 0.1938 mL | 0.4845 mL | |
| 60 mM | 0.0161 mL | 0.0807 mL | 0.1615 mL | 0.4037 mL | |
| 80 mM | 0.0121 mL | 0.0606 mL | 0.1211 mL | 0.3028 mL |
MC-Gly-Gly-Phe-Gly-GABA-Exatecan Related Classifications
HY-160649 Related Classifications
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