2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. MC-Gly-Gly-Phe-Gly-GABA-Exatecan

MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo.

For research use only. We do not sell to patients.

MC-Gly-Gly-Phe-Gly-GABA-Exatecan Chemical Structure

MC-Gly-Gly-Phe-Gly-GABA-Exatecan Chemical Structure

CAS No. : 1599439-52-7

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5 mg USD 600 In-stock
10 mg USD 960 In-stock
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Based on 1 publication(s) in Google Scholar

MC-Gly-Gly-Phe-Gly-GABA-Exatecan Related Antibodies

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  • Biological Activity

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Description

MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo[1][2].

IC50 & Target

Camptothecins

 

In Vitro

MC-Gly-Gly-Phe-Gly-GABA-Exatecan (0-10 μM) exhibits cytotoxicity in cells SR (CD30 positive), HL60 (CD33 positive), U251 (CD70 positive) and Calu-6 (B7-H3 positive) through functions with CD30, CD33, CD70 and B7-H3[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC-Gly-Gly-Phe-Gly-GABA-Exatecan Related Antibodies

Cell Viability Assay[2]

Cell Line: SR, HL60, U251 and Calu-6
Concentration: 0-10 μM
Incubation Time: 6 days
Result: Reduced cell viability.
In Vivo

MC-Gly-Gly-Phe-Gly-GABA-Exatecan (10 mg/kg, i.v. once a week for 2 weeks) exhibits antitumor efficacy in A375 xenograft mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A375 xenograft mice[2]
Dosage: 10 mg/kg
Administration: i.v, once a week for 2 weeks
Result: Inhibited tumor growth and induced tumor regression.
Molecular Weight

1032.08

Formula

C53H58FN9O12
CAS No.
Appearance

Solid

SMILES

O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCCCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (96.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9689 mL 4.8446 mL 9.6892 mL
5 mM 0.1938 mL 0.9689 mL 1.9378 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9689 mL 4.8446 mL 9.6892 mL 24.2229 mL
5 mM 0.1938 mL 0.9689 mL 1.9378 mL 4.8446 mL
10 mM 0.0969 mL 0.4845 mL 0.9689 mL 2.4223 mL
15 mM 0.0646 mL 0.3230 mL 0.6459 mL 1.6149 mL
20 mM 0.0484 mL 0.2422 mL 0.4845 mL 1.2111 mL
25 mM 0.0388 mL 0.1938 mL 0.3876 mL 0.9689 mL
30 mM 0.0323 mL 0.1615 mL 0.3230 mL 0.8074 mL
40 mM 0.0242 mL 0.1211 mL 0.2422 mL 0.6056 mL
50 mM 0.0194 mL 0.0969 mL 0.1938 mL 0.4845 mL
60 mM 0.0161 mL 0.0807 mL 0.1615 mL 0.4037 mL
80 mM 0.0121 mL 0.0606 mL 0.1211 mL 0.3028 mL
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MC-Gly-Gly-Phe-Gly-GABA-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Gly-Gly-Phe-Gly-GABA-Exatecan1599439-52-7Drug-Linker Conjugates for ADCTopoisomeraseSRHL60U251Calu-6CD30CD33CD70B7-H3,A375Inhibitorinhibitorinhibit

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