Ddr1 - discoidin domain receptor tyrosine kinase 1 Gene

Also Known as Cak; Drd1; PTK3D

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25678

About Ddr1

Primary_assembly 20: 3,044,320-3,064,468 forward strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 196 orthologues, 54 paralogues and is associated with 31 phenotypes. Biased expression in Kidney (RPKM 22.8), Brain (RPKM 117.8) and 8 other tissues.

Summary

Predicted to enable Collagen binding activity and protein tyrosine kinase Collagen receptor activity. Involved in animal organ regeneration and skin development. Located in basolateral plasma membrane; brush border; and cytoplasm. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human DDR1 (Discoidin Domain Receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ddr1 Products (2)

mRNA Protein Name
NM_013137.2 NP_037269.2 epithelial discoidin domain-containing receptor 1 precursor
NM_001166022.1 NP_001159494.1 epithelial discoidin domain-containing receptor 1 precursor

Ddr1 Protein Structure

FA58C

FA58C: cd00057 (57 - 184)

PTKc_DDR1

PTKc_DDR1: cd05096 (600 - 903)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 910 a.a.
Protein Preferred Names Protein Names

epithelial discoidin domain-containing receptor 1

  • CD167 antigen-like family member A

  • cell adhesion kinase

  • discoidin domain receptor family, member 1

  • discoidin receptor tyrosine kinase

  • epithelial discoidin domain receptor 1

  • neurotrophic tyrosine kinase receptor type 4

  • protein-tyrosine kinase 3

  • protein-tyrosine kinase PTK-3

  • tyrosine kinase DDR

  • tyrosine-protein kinase CAK

Recombinant Ddr1 Proteins

Cat. No. Product Name Accession Purity
HY-P75299 DDR1 Protein, Rat (HEK293, His) Q6MG19 (D22-T413) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75300 DDR1 Protein, Rat (HEK293, hFc) Q6MG19 (D20-T413) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16961 Sitravatinib Inhibitor 99.57% Phase 3
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135401 VU6015929 Inhibitor 99.50% Unkown
HY-114173 DDR1-IN-4 Inhibitor 98.19% Unkown
HY-NP175 Collagen (bovine skin) Ligand / Unkown
HY-133670 DDR1-IN-6 Inhibitor 98.02% Unkown
HY-156552 DDR1/2 inhibitor-2 Inhibitor 99.73% Unkown
HY-13979A DDR1-IN-1 dihydrochloride Inhibitor 98.92% Unkown
HY-133669 DDR1-IN-5 Inhibitor 99.65% Unkown
HY-167208 SR-302 Inhibitor 98.51% Unkown
HY-176184 PROTAC DDR1 degrader-1 Degrader 98.69% Unkown
HY-183068 AP4-43 Inhibitor 99.76% Unkown
HY-16961A Sitravatinib malate Inhibitor / Unkown
HY-187094 7rh-C2-O-Boc Ligand / Unkown
HY-175281 SJ11646 Degrader 99.3% Unkown
HY-187093 7rh-Boc Ligand / Unkown
HY-173284 DDR1-IN-11 Inhibitor / Unkown
HY-181839 DDR1/2 IN-4 Inhibitor / Unkown
HY-179535 Axl-IN-21 Inhibitor / Unkown
HY-176185 DDR1 ligand 1 / Unkown
HY-122848 DDR1/2 inhibitor-3 Inhibitor / Unkown
HY-162102 DDR1-IN-8 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddr1 NCBI NCBI:780