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  5. Adenine hydrochloride

Adenine hydrochloride  (Synonyms: 6-Aminopurine hydrochloride; Vitamin B4 hydrochloride)

Cat. No.: HY-B0152A Purity: ≥98.0%
SDS COA Handling Instructions

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Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

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Adenine hydrochloride Chemical Structure

Adenine hydrochloride Chemical Structure

CAS No. : 2922-28-3

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Based on 10 publication(s) in Google Scholar

Other Forms of Adenine hydrochloride:

Adenine hydrochloride Related Antibodies

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Description

Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vivo

Adenine hydrochloride can be used to induce chronic liver injury models. Pharmacokinetic data show that in adult male Sprague-Dawley rats, 20-30 minutes after administration (10 mg/kg, i.v.), the Adenine content in blood dialysate samples is 0.78 μg/mL[4].

Induction of Chronic Kidney Disease (CKD)[4][5][6]
Background
Adenine is metabolized by the liver to form dihydroxyadenine, which is insoluble in water. The latter is deposited in the kidneys, which can cause post-renal obstruction, affect uric acid excretion, and cause kidney damage.
Specific Mmodeling Methods
Mice: C57BL/6J • 8 weeks of age
Administration: 0.2% Adenine in diet; 3 weeks
Rat: Sprague–Dawley (SD) • male • 8 weeks of age
Administration: 0.5% Adenine in diet; 3 weeks
Note
Modeling Indicators
Biochemical changs: KW-to-BW ratio increasing; Systolic and diastotic blood pressure increasing; Blood urea nitrogen increasing; serum creatinine levels increasing
Correlated Product(s): /
Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

171.59

Formula

C5H6ClN5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=C2N=CNC2=NC=N1.Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (291.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (58.28 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8278 mL 29.1391 mL 58.2781 mL
5 mM 1.1656 mL 5.8278 mL 11.6556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (254 KB) HNMR (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.8278 mL 29.1391 mL 58.2781 mL 145.6953 mL
5 mM 1.1656 mL 5.8278 mL 11.6556 mL 29.1391 mL
10 mM 0.5828 mL 2.9139 mL 5.8278 mL 14.5695 mL
15 mM 0.3885 mL 1.9426 mL 3.8852 mL 9.7130 mL
20 mM 0.2914 mL 1.4570 mL 2.9139 mL 7.2848 mL
25 mM 0.2331 mL 1.1656 mL 2.3311 mL 5.8278 mL
30 mM 0.1943 mL 0.9713 mL 1.9426 mL 4.8565 mL
40 mM 0.1457 mL 0.7285 mL 1.4570 mL 3.6424 mL
50 mM 0.1166 mL 0.5828 mL 1.1656 mL 2.9139 mL
DMSO 60 mM 0.0971 mL 0.4857 mL 0.9713 mL 2.4283 mL
80 mM 0.0728 mL 0.3642 mL 0.7285 mL 1.8212 mL
100 mM 0.0583 mL 0.2914 mL 0.5828 mL 1.4570 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Adenine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenine2922-28-36-AminopurineVitamin B4Vitamin B 4Vitamin B-4DNA/RNA SynthesisEndogenous MetabolitepurineDNAnucleobaseInhibitorinhibitorinhibit

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