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  5. Adenine hydrochloride

Adenine hydrochloride  (Synonyms: 6-Aminopurine hydrochloride; Vitamin B4 hydrochloride)

Cat. No.: HY-B0152A Purity: 98.0%
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Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

For research use only. We do not sell to patients.

CAS No. : 2922-28-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
500 mg In-stock
1 g In-stock
5 g In-stock
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50 g   Get quote  

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Based on 22 publication(s) in Google Scholar

Other Forms of Adenine hydrochloride:

Adenine hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Adenine hydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin (10 and 15mg/kg, i.p.,once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. Representative images of MTS (blue color), Picrosirius Red staining (red color), and IF staining of fibronectin (red color) and COL1A1 (green color) for kidney sections from adenine-fed (Adenine) or normal-fed (Ctrl) mice. Scale bars are 50 μm.

    Adenine hydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin (10 and 15 mg/kg, i.p., once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. WB images of fibronectin and COL1A1 expressions in kidney lysates from mice.

    Adenine hydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved survival rate of Adenine (0.25% w/w)-fed mice. (A) Relative weight curves of indicated mice as described in A (n = 6). Mouse weight is measured once per 3 days, the initial weight is set to 1, and day 0 means the time point starting Adenine-rich diet. (B) Kaplan-Meier survival analysis of indicated mice as described in A (n = 12). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

    Adenine hydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved kidney function of Adenine (0.25% w/w)-fed mice. Concentrations of serum creatinine, urea, and albumin from mice (n = 8). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

    Adenine hydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) treatment prevented phenotypic alteration of tubular epithelial cells in the kidneys from Adenine (ADE) (0.25% w/w)-fed mice. Representative IHC staining images of E-cadherin and vimentin kidney sections from mice. Scale bars are 25 μm.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Adenine hydrochloride can be used to induce chronic liver injury models. Pharmacokinetic data show that in adult male Sprague-Dawley rats, 20-30 minutes after administration (10 mg/kg, i.v.), the Adenine content in blood dialysate samples is 0.78 μg/mL[4].

    Induction of Chronic Kidney Disease (CKD)[4][5][6]
    Background
    Adenine is metabolized by the liver to form dihydroxyadenine, which is insoluble in water. The latter is deposited in the kidneys, which can cause post-renal obstruction, affect uric acid excretion, and cause kidney damage.
    Specific Modeling Methods
    Mice: C57BL/6J • 8 weeks of age
    Administration: 0.2% Adenine in diet; 3 weeks
    Rat: Sprague-Dawley (SD) • male • 8 weeks of age
    Administration: 0.5% Adenine in diet; 3 weeks
    Note
    Modeling Indicators
    Biochemical changs: KW-to-BW ratio increasing; Systolic and diastotic blood pressure increasing; Blood urea nitrogen increasing; serum creatinine levels increasing

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    171.59

    Formula

    C5H6ClN5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NC1=C2N=CNC2=NC=N1.Cl
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (291.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 10 mg/mL (58.28 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.8278 mL 29.1392 mL 58.2785 mL
    5 mM 1.1656 mL 5.8278 mL 11.6557 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 98.0%

    SDS (396 KB)

    COA (254 KB) HNMR (139 KB) MS (117 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 5.8278 mL 29.1392 mL 58.2785 mL 145.6961 mL
    5 mM 1.1656 mL 5.8278 mL 11.6557 mL 29.1392 mL
    10 mM 0.5828 mL 2.9139 mL 5.8278 mL 14.5696 mL
    15 mM 0.3885 mL 1.9426 mL 3.8852 mL 9.7131 mL
    20 mM 0.2914 mL 1.4570 mL 2.9139 mL 7.2848 mL
    25 mM 0.2331 mL 1.1656 mL 2.3311 mL 5.8278 mL
    30 mM 0.1943 mL 0.9713 mL 1.9426 mL 4.8565 mL
    40 mM 0.1457 mL 0.7285 mL 1.4570 mL 3.6424 mL
    50 mM 0.1166 mL 0.5828 mL 1.1656 mL 2.9139 mL
    DMSO 60 mM 0.0971 mL 0.4857 mL 0.9713 mL 2.4283 mL
    80 mM 0.0728 mL 0.3642 mL 0.7285 mL 1.8212 mL
    100 mM 0.0583 mL 0.2914 mL 0.5828 mL 1.4570 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Adenine hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Adenine2922-28-36-AminopurineVitamin B4Vitamin B 4Vitamin B-4DNA/RNA SynthesisEndogenous MetabolitepurineDNAnucleobaseInhibitorinhibitorinhibit

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