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Cat. No.: HY-A0070AG

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Liothyronine (GMP)

(Synonyms: Triiodothyronine (GMP); 3,3',5-Triiodo-L-thyronine (GMP); T3 (GMP))

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively.

For research use only. We do not sell to patients.

CAS No.: 6893-02-3
Formula: C₁₅H₁₂I₃NO₄
Molecular Weight:650.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Liothyronine (GMP) Chemical Structure

CAS No.: 6893-02-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

TRβ1^[1]^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	3.4 nM Compound: T3	Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assay Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assay	[PMID: 32356658]
CHO	EC₅₀	6.2 nM Compound: T3	Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assay Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assay	[PMID: 32356658]
CHO-K1	IC₅₀	0.24 nM Compound: 1	Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells	[PMID: 17543524]
CHO-K1	IC₅₀	0.26 nM Compound: 1	Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells	[PMID: 17543524]
CV-1	EC₅₀	0.002 μM Compound: T3	Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay	[PMID: 24290064]
CV-1	EC₅₀	0.0021 μM Compound: T3	Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay	[PMID: 24290064]
CV-1	EC₅₀	0.5 nM Compound: T3	Agonist activity at Xenopus laevis THRalpha transfected in green monkey CV1 cells after 48 hrs by reporter gene assay Agonist activity at Xenopus laevis THRalpha transfected in green monkey CV1 cells after 48 hrs by reporter gene assay	[PMID: 32356658]
CV-1	EC₅₀	1.2 nM Compound: T3	Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assay Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assay	[PMID: 32356658]
HEK293	EC₅₀	0.41 nM Compound: T3	Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]
HEK-293T	EC₅₀	5.8 μM Compound: T3	Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay	[PMID: 32356658]
HeLa	EC₅₀	2.4 nM Compound: T3	Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay	[PMID: 17988877]
HeLa	EC₅₀	2.4 nM Compound: T3	Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay	[PMID: 17988877]
LNCaP	IC₅₀	>50 μM Compound: 6, T3	Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis	[PMID: 22047606]
Oocyte	IC₅₀	50.4 μM Compound: Triiodothyronine	TP_TRANSPORTER: inhibition of Digoxin uptake in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of Digoxin uptake in Xenopus laevis oocytes	[PMID: 11561088]
Sf9	EC₅₀	0.5 nM Compound: T3	Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresis Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresis	[PMID: 32356658]
U2OS	EC₅₀	11 nM Compound: T3	Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay	[PMID: 17988877]
U2OS	EC₅₀	2.4 nM Compound: T3	Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay	[PMID: 17988877]

In Vitro

Liothyronine (GMP) can be used in culture medium for generation of induced pluripotent stem cells from human keratinocytes^[1].
Liothyronine (GMP) is necessary in limbal stem cells (LSCs) proliferation and self-renewal^[2].
Liothyronine (GMP) (4 nM) promotes cardiac differentiation and maturation of embryonic stem cells^[3].
Liothyronine (GMP) (100 Nm, 14 days) promotes electrophysiological maturation of human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6893-02-3
Appearance Solid
Molecular Weight 650.97
Formula C₁₅H₁₂I₃NO₄
Color White to off-white
SMILES

OC1=C(I)C=C(OC2=C(I)C=C(C[C@H](N)C(O)=O)C=C2I)C=C1
Synonyms

Triiodothyronine (GMP); 3,3',5-Triiodo-L-thyronine (GMP); T3 (GMP)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Acta Pharm Sin B

2025 Nov 13.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aasen T, et al. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat Protoc. 2010 Feb;5(2):371-82. [Content Brief]

[2]. Yu M, et al. An important role for adenine, cholera toxin, hydrocortisone and triiodothyronine in the proliferation, self-renewal and differentiation of limbal stem cells in vitro. Exp Eye Res. 2016 Nov;152:113-122. [Content Brief]

[3]. CY, et al. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol Endocrinol. 2010 Sep;24(9):1728-36. [Content Brief]

[4]. Wang L, et al. Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2021 Dec;161:130-138. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Liothyronine (GMP)

1 Cited Publications

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Purity & Documentation
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Liothyronine (GMP)

Publications Citing Use of MedChemExpress (MCE) Liothyronine (GMP)

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Liothyronine (GMP) Related Classifications

HY-A0070AG Related Classifications