Liothyronine  (Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

Liothyronine (Triiodothyronine) (GMP) is Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively^[1].

TRβ1^[1][2]

Liothyronine (GMP) can be used in culture medium for generation of induced pluripotent stem cells from human keratinocytes^[1].
Liothyronine (GMP) is necessary in limbal stem cells (LSCs) proliferation and self-renewal^[2].
Liothyronine (GMP) (4 nM) promotes cardiac differentiation and maturation of embryonic stem cells^[3].
Liothyronine (GMP) (100 Nm, 14 days) promotes electrophysiological maturation of human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

650.97

C₁₅H₁₂I₃NO₄

6893-02-3

OC1=C(I)C=C(OC2=C(I)C=C(C[C@H](N)C(O)=O)C=C2I)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Aasen T, et al. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat Protoc. 2010 Feb;5(2):371-82.  [Content Brief]

  [2]. Yu M, et al. An important role for adenine, cholera toxin, hydrocortisone and triiodothyronine in the proliferation, self-renewal and differentiation of limbal stem cells in vitro. Exp Eye Res. 2016 Nov;152:113-122.  [Content Brief]

  [3]. CY, et al. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol Endocrinol. 2010 Sep;24(9):1728-36.  [Content Brief]

  [4]. Wang L, et al. Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2021 Dec;161:130-138.  [Content Brief]