2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. Liothyronine

Liothyronine  (Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

Cat. No.: HY-A0070AG
SDS
Handling Instructions Technical Support

Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.

For research use only. We do not sell to patients.

Liothyronine

Liothyronine Chemical Structure

CAS No. : 6893-02-3

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Liothyronine:

Liothyronine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Liothyronine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1].

IC50 & Target

TRβ1[1][2]
Cellular Effect
Cell Line Type Value Description References
CHO EC50
3.4 nM
Compound: T3
Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assay
Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assay
[PMID: 32356658]
CHO EC50
6.2 nM
Compound: T3
Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assay
Agonist activity at human THRbeta expressed in CHO cells after 24 hrs by luciferase assay
[PMID: 32356658]
CHO-K1 IC50
0.24 nM
Compound: 1
Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells
Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells
[PMID: 17543524]
CHO-K1 IC50
0.26 nM
Compound: 1
Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells
Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells
[PMID: 17543524]
CV-1 EC50
0.002 μM
Compound: T3
Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay
Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay
[PMID: 24290064]
CV-1 EC50
0.0021 μM
Compound: T3
Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay
Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assay
[PMID: 24290064]
CV-1 EC50
0.5 nM
Compound: T3
Agonist activity at Xenopus laevis THRalpha transfected in green monkey CV1 cells after 48 hrs by reporter gene assay
Agonist activity at Xenopus laevis THRalpha transfected in green monkey CV1 cells after 48 hrs by reporter gene assay
[PMID: 32356658]
CV-1 EC50
1.2 nM
Compound: T3
Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assay
Agonist activity at human THRbeta expressed in green monkey CV1 cells after 24 hrs by luciferase assay
[PMID: 32356658]
HEK-293T EC50
5.8 μM
Compound: T3
Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay
Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK293T cells transfected with pFR-luciferase plasmid and pRL-SV40 plasmid incubated for 14 to 16 hrs by dual glo luciferase reporter gene assay
[PMID: 32356658]
HEK293 EC50
0.41 nM
Compound: T3
Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 25305688]
HeLa EC50
2.4 nM
Compound: T3
Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay
Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay
[PMID: 17988877]
HeLa EC50
2.4 nM
Compound: T3
Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay
Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay
[PMID: 17988877]
LNCaP IC50
> 50 μM
Compound: 6, T3
Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis
Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis
[PMID: 22047606]
Oocyte IC50
50.4 μM
Compound: Triiodothyronine
TP_TRANSPORTER: inhibition of Digoxin uptake in Xenopus laevis oocytes
TP_TRANSPORTER: inhibition of Digoxin uptake in Xenopus laevis oocytes
[PMID: 11561088]
Sf9 EC50
0.5 nM
Compound: T3
Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresis
Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresis
[PMID: 32356658]
U2OS EC50
11 nM
Compound: T3
Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay
Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay
[PMID: 17988877]
U2OS EC50
2.4 nM
Compound: T3
Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay
Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay
[PMID: 17988877]
In Vitro

Liothyronine (GMP) can be used in culture medium for generation of induced pluripotent stem cells from human keratinocytes[1].
Liothyronine (GMP) is necessary in limbal stem cells (LSCs) proliferation and self-renewal[2].
Liothyronine (GMP) (4 nM) promotes cardiac differentiation and maturation of embryonic stem cells[3].
Liothyronine (GMP) (100 Nm, 14 days) promotes electrophysiological maturation of human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Liothyronine Related Antibodies
Molecular Weight

650.97

Formula

C15H12I3NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(I)C=C(OC2=C(I)C=C(C[C@H](N)C(O)=O)C=C2I)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Liothyronine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Liothyronine (GMP)6893-02-3Triiodothyronine (GMP) 3,3',5-Triiodo-L-thyronine (GMP) T3 (GMP)Thyroid Hormone ReceptorTHRGMPcell therapydifferentiatestem cellLSCsInhibitorinhibitorinhibit

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