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  3. NH-3

NH-3 

Cat. No.: HY-141513
Handling Instructions

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.

For research use only. We do not sell to patients.

NH-3 Chemical Structure

NH-3 Chemical Structure

CAS No. : 447415-26-1

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Description

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3].

IC50 & Target

IC50: 55 nM (THR)[1]

In Vivo

NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

473.52

Formula

C₂₈H₂₇NO₆

CAS No.
SMILES

O=C(O)COC1=CC(C)=C(CC2=CC(C#CC3=CC=C([N+]([O-])=O)C=C3)=C(O)C(C(C)C)=C2)C(C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NH-3NH3NH 3Thyroid Hormone ReceptorTHRorallythyromi-meticGC-1cofactorrecruitmentInhibitorinhibitorinhibit

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NH-3
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HY-141513
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