2128258-47-7
Chemical Structure
Sob-AM2
- CAS 番号: 2128258-47-7
- Formula:C21H27NO3
- Molecular Weight:341.44
InChIKey: UWVFEENBJKSTRD-UHFFFAOYSA-N
SMILES: O=C(COC1=CC(C)=C(CC2=CC=C(C(C(C)C)=C2)O)C(C)=C1)NC
Biological Activity: Sob-AM2 is a potent substrate (Km=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice[1].
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Sob-AM2 | 98.5% | Sob-AM2 is a potent substrate (Km=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice. | ||||||||||||||||||||
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