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  2. Thyroid Hormone Receptor
  3. MB-07344

MB-07344 

Cat. No.: HY-19513 Purity: 98.12%
Handling Instructions

MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys.

For research use only. We do not sell to patients.

MB-07344 Chemical Structure

MB-07344 Chemical Structure

CAS No. : 852947-39-8

Size Price Stock Quantity
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 980 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MB-07344:

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Description

MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys[1].

IC50 & Target

Ki: 2.17 nM (Thyroid hormone receptor-β)[1]

In Vivo

MB-07344 (0.05 mg/kg; i.v.; 3 times per week for 3 weeks) results in adjunctive and additive activity when given in combination with Atorvastatin in normal rabbits[1].

Animal Model: Normal rabbits[1]
Dosage: 0.05 mg/kg
Administration: Given i.v., 3 times per week for 3 weeks
Result: Combination with atorvastatin further reduced cholesterol.
Molecular Weight

364.37

Formula

C₁₉H₂₅O₅P

CAS No.

852947-39-8

SMILES

CC1=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=CC(OCP(O)(O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (686.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7445 mL 13.7223 mL 27.4446 mL
5 mM 0.5489 mL 2.7445 mL 5.4889 mL
10 mM 0.2744 mL 1.3722 mL 2.7445 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (17.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (17.15 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (17.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MB-07344MB07344MB 07344Thyroid Hormone ReceptorTHRcholesterolhypercholesterolaemialipoproteinliver-targetedprodruglow-densityInhibitorinhibitorinhibit

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Product name:
MB-07344
Cat. No.:
HY-19513
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