FAAH-IN-10
FAAH-IN-10 is a FAAH inhibitor and TRPV1 antagonist, with an IC50 of 0.57 μM against human FAAH. FAAH-IN-10 regulates FAAH activity, antagonizes TRPV1 activity, and exhibits analgesic and anti-inflammatory activities. FAAH-IN-10 does not induce TRPV1-mediated hyperthermia. FAAH-IN-10 can be used for pain-related research.
For research use only. We do not sell to patients.
- Formula: C24H25N3O3S
- Molecular Weight:435.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TRPV1 |
FAAH-IN-10 (Compound 31) potently inhibits capsaicin-induced activation of human TRPV1-transfected HEK-293 cells with an IC50 of 18.81 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
FAAH-IN-10 (5-20 mg/kg; i.p.; single dose) demonstrates dose-dependent anti-inflammatory activity in a carrageenan-induced paw edema model, with greater efficacy than AA-5-HT at equivalent and higher doses[1].
FAAH-IN-10 (5 mg/kg; i.p.; single dose) does not induce TRPV1-mediated hyperthermia in mice at therapeutic doses, maintaining stable core body temperature comparable to vehicle controls[1].
FAAH-IN-10 (10-40 mg/kg; i.p.; single dose) produces dose-dependent analgesia mediated by TRPV1 antagonism in a capsaicin-induced pain model[1].
FAAH-IN-10 (30 mg/kg; i.p.; single dose) exerts part of its analgesic effect via FAAH inhibition, as demonstrated by reversal of efficacy with the CB1 receptor antagonist AM251[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (male, 22-35 g)[1]
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Dosage:10 mg/kg; 20 mg/kg; 30 mg/kg; 40 mg/kg
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Administration:i.p.; single dose
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Result:Significantly reduced licking/biting time in both phase I and phase II at 30 mg/kg, with greater efficacy than positive control AA-5-HT.
Reduced phase II licking/biting time in a dose-dependent manner at 10, 20, and 40 mg/kg.
Significantly reduced phase I licking/biting time compared to vehicle at 40 mg/kg.
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Animal Model:unstated strain[1]
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Dosage:5 mg/kg; 10 mg/kg; 20 mg/kg
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Administration:i.p.; single dose
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Result:Exhibited superior anti-edema effects relative to AA-5-HT (5 mg/kg) at 5, 10, and 20 mg/kg.
Showed a clear dose-response relationship, with escalating doses producing progressively greater inhibition of paw edema.
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Animal Model:unstated strain[1]
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Dosage:5 mg/kg; graded unspecified doses
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Administration:i.p.; single dose
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Result:Did not produce a statistically significant increase in core body temperature at any time point up to 180 minutes post-injection, unlike BCTC.
Showed no significant differences in rectal temperature between compound 31-treated groups and vehicle group at all assessed time points in follow-up dose-ranging study.
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Animal Model:Kunming mice (male, 22-35 g)[1]
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Dosage:10 mg/kg; 20 mg/kg; 40 mg/kg
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Administration:i.p.; single dose
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Result:Significantly reduced licking duration in a dose-dependent manner, with greater reductions observed at higher doses.
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Animal Model:Kunming mice (male, 22-35 g)[1]
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Dosage:30 mg/kg
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Administration:i.p.; single dose
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Result:Significantly shortened formalin-induced phase II licking/biting time compared to vehicle.
Had its analgesic effect reversed by pretreatment with AM251, which significantly prolonged licking/biting duration.
Chemical Information
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Molecular Weight 435.54
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Formula C24H25N3O3S
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SMILES
O=C(OC1=CC=CC=C1)NCCCC(N2[C@H](C3=NC(C4=CC=CC=C4)=CS3)CCC2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAAH-IN-10 Related Classifications
HY-184331 Related Classifications
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- FAAH-IN-10
- FAAH
- TRP Channel
- carrageenan-induced paw edema model
- human TRPV1-transfected HEK-293 cells
- mice
- CB receptor
- capsaicin-induced pain model
- human recombinant FAAH enzyme
- human FAAH
- formalin-induced pain model
- transient receptor potential vanilloid type 1
- fatty acid amide hydrolase
- Inhibitor
- inhibitor
- inhibit