EphA1 Protein, Human (HEK293, hFc)
Based on 1 Customer Validation
EphA1 Protein, a receptor tyrosine kinase, engages in bidirectional signaling with membrane-bound ephrin-A ligands. Activation by EFNA1 regulates cell attachment, motility, angiogenesis, and proliferation. EphA1 may also play a role in apoptosis. EphA1 Protein, Human (HEK293, hFc) is the recombinant human-derived EphA1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
EphA1 Protein, a receptor tyrosine kinase, engages in bidirectional signaling with membrane-bound ephrin-A ligands. Activation by EFNA1 regulates cell attachment, motility, angiogenesis, and proliferation. EphA1 may also play a role in apoptosis. EphA1 Protein, Human (HEK293, hFc) is the recombinant human-derived EphA1 protein, expressed by HEK293 , with C-hFc labeled tag.
Background
EphA1 protein is a receptor tyrosine kinase that interacts with membrane-bound ephrin-A ligands on neighboring cells, resulting in contact-dependent bidirectional signaling. This receptor mediates both forward signaling and reverse signaling pathways. Activation by its high-affinity ligand EFNA1 regulates various cellular processes, including cell attachment, motility, angiogenesis, and proliferation. Additionally, EphA1 may play a role in apoptosis.
Verified Bioactivity
1.This product does not contain protein kinase domain.
2.Immobilized human EFNA1-His at 10 μg/ml (100 μL /well) can bind human EPHA1-Fc, The EC50 of human EPHA1-Fc is 9.6-30 ng/mL.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-hFc
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Accession
EAL23789.1 (K26-E547)
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Molecular Construction
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N-term
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EphA1 (K26-E547)
Accession # EAL23789.1 -
hFc
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C-term
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Protein Length
Extracellular Domain
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Synonyms
EPHA1; HEpha1; Prev. EPHT1; Alternative Protein EPHA1; Prev. EPHT; Eph Tyrosine Kinase 1; EPH; EPH Tyrosine Kinase 1; Erythropoietin-Producing Hepatoma Receptor; EPH Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EPH; Oncogene EPH; Ephrin Type-A Recept
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AA Sequence
KEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLASGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGE
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Predicted Molecular Mass
83.3 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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