EPHA1 - EPH receptor A1 Gene

Also Known as EPH; EPHT; EPHT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2041

About EPHA1

Cytogenetic location: 7q34-q35 Genomic coordinates (GRCh38): 7:143,391,129-143,408,856 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 124 orthologues and 53 paralogues. Ubiquitous expression in esophagus (RPKM 21.6), skin (RPKM 11.4) and 25 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human Cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

EPHA1 Products (1)

mRNA Protein Name
NM_005232.5 NP_005223.4 ephrin type-A receptor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibronectin binding IDA
IDA: Inferred from direct assay
18308734 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
12775584 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19118217 GOA
enables transmembrane-ephrin receptor activity IDA
IDA: Inferred from direct assay
19118217 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
19118217 GOA
involved in cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
19118217 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
19118217 GOA
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
19118217 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
12775584 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
20043122 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20043122 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20043122 GOA
involved in positive regulation of cell-matrix adhesion IDA
IDA: Inferred from direct assay
19118217 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
19118217 GOA
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
19118217 GOA
involved in substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
19118217 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
16862074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA1 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (27 - 204)

fn3

fn3: Fibronectin type III domain (334 - 428)

fn3

fn3: Fibronectin type III domain (455 - 528)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (550 - 621)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (626 - 880)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (914 - 975)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 976 a.a.
Protein Preferred Names Protein Names

ephrin type-A receptor 1

  • eph tyrosine kinase 1

Recombinant EPHA1 Proteins

Cat. No. Product Name Accession Purity
HY-P70321 EphA1 Protein, Human (HEK293, His) AAI30292.1 (K26-E547) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75242 EphA1 Protein, Human (HEK293, hFc) EAL23789.1 (K26-E547) ≥ 90%, as determined by reducing SDS-PAGE.

EPHA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84180 EphA1 Antibody (YA3877) WB, IHC-P, ELISA Human
HY-P84180A EphA1 Antibody (YA3877)(PBS only) WB, IHC-P, ELISA Human
HY-P85136 EphA1 Antibody (YA4828) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Craniofrontonasal Syndrome

  • Craniofrontonasal Dysplasia

  • CFNS

  • Cfnd

  • Craniofrontonasal Dysostosis

  • Craniofrontonasal Dystosis

  • Dysplasia, Craniofrontonasal
Liver Carcinoma In Situ

  • Carcinoma In Situ Of Liver And Biliary System

  • Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Retinitis Pigmentosa 18

  • RP18

  • Retinitis Pigmentosa-18

  • Retinitis Pigmentosa, Type 18
Alzheimer Disease 4

  • AD4

  • Alzheimer Disease-4

  • Alzheimer'S Disease 4

  • Alzheimer Disease, Familial, 4

  • Alzheimer Disease, Familial4

  • Alzheimer'S Disease 4, Early Onset

  • Alzheimer Disease, Type 4
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Leukodystrophy, Hypomyelinating, 5

  • Hypomyelination And Congenital Cataract

  • HLD5

  • Hypomyelination-Congenital Cataract Syndrome

  • Hypomyelinating Leukodystrophy 5

  • Hcc

  • Hypomyelination And Congenital Cataract: Hcc

  • Hypomyelination - Congenital Cataract

  • Hypomyelination With Congenital Cataract
Saethre-Chotzen Syndrome

  • SCS

  • Acs3

  • Acs Iii

  • Chotzen Syndrome

  • Acrocephaly, Skull Asymmetry, And Mild Syndactyly

  • Acrocephalosyndactyly Type 3

  • Acrocephalosyndactyly, Type Iii

  • Acrocephalosyndactyly Type Iii

  • Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies

  • Auralcephalosyndactyly

  • Acs 3

  • Acrocephalo-Syndactyly, Type 3

  • Blepharophimosis,Epicanthus Inversus, And Ptosis 3

  • Aural Cephalosyndactyly

  • Kurczynski-Casperson Syndrome

  • Acrocephalosyndactyly Iii

  • Dysostosis Craniofacialis With Hypertelorism

  • Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies

  • Sakati Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W074890 Palmitoylglycine Modulator 99.84% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-RS04424 EPHA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19190 Epha1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25678 Epha1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EPHA1 RGD RGD:1304680
Bos taurus EPHA1 VGNC VGNC:28532
Canis familiaris EPHA1 VGNC VGNC:40404
Felis catus EPHA1 VGNC VGNC:61901
Macaca mulatta EPHA1 VGNC VGNC:108400
Mus musculus EPHA1 MGD MGI:107381
Others EPHA1 NCBI