EPHA1 - EPH receptor A1 Gene

Homo sapiens

Also known as EPH; EPHT; EPHT1

Gene ID: 2041 | Gene type: protein coding

About EPHA1

Cytogenetic location: 7q34-q35 Genomic coordinates (GRCh38): 7:143,391,129-143,408,856 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 124 orthologues and 53 paralogues. Ubiquitous expression in esophagus (RPKM 21.6), skin (RPKM 11.4) and 25 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human Cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

EPHA1 Products(1)

mRNA	Protein	Name
NM_005232.5	NP_005223.4	ephrin type-A receptor 1 precursor

EPHA1 Protein Structure

Ephrin_lbd

fn3

EphA2_TM

Pkinase_Tyr

SAM_1

0
200
400
600
800
976 a.a.

Protein Preferred Names

Protein Names

ephrin type-A receptor 1

eph tyrosine kinase 1

Recombinant EPHA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70321	EphA1 Protein, Human (522a.a, HEK293, His)	AAI30292.1 (K26-E547)	≥95%
HY-P75242	EphA1 Protein, Human (HEK293, hFc)	P21709 (M1-E547)	≥95%
HY-P75243	EphA1 Protein, Human (547a.a, HEK293, His)	P21709 (M1-E547)	≥95%

Related Diseases

Diseases

Alias

Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia	CFNS
Cfnd	Craniofrontonasal Dysostosis
Craniofrontonasal Dystosis	Dysplasia, Craniofrontonasal

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Retinitis Pigmentosa 18

RP18	Retinitis Pigmentosa-18
Retinitis Pigmentosa, Type 18

Alzheimer Disease 4

AD4	Alzheimer Disease-4
Alzheimer'S Disease 4	Alzheimer Disease, Familial, 4
Alzheimer Disease, Familial4	Alzheimer'S Disease 4, Early Onset
Alzheimer Disease, Type 4

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Leukodystrophy, Hypomyelinating, 5

Hypomyelination And Congenital Cataract	HLD5
Hypomyelination-Congenital Cataract Syndrome	Hypomyelinating Leukodystrophy 5
Hcc	Hypomyelination And Congenital Cataract: Hcc
Hypomyelination - Congenital Cataract	Hypomyelination With Congenital Cataract

Saethre-Chotzen Syndrome

SCS	Acs3
Acs Iii	Chotzen Syndrome
Acrocephaly, Skull Asymmetry, And Mild Syndactyly	Acrocephalosyndactyly Type 3
Acrocephalosyndactyly, Type Iii	Acrocephalosyndactyly Type Iii
Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies	Auralcephalosyndactyly
Acs 3	Acrocephalo-Syndactyly, Type 3
Blepharophimosis,Epicanthus Inversus, And Ptosis 3	Aural Cephalosyndactyly
Kurczynski-Casperson Syndrome	Acrocephalosyndactyly Iii
Dysostosis Craniofacialis With Hypertelorism	Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies
Sakati Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148065	FMF-06-098-1		/	Unkown
HY-RS04424	EPHA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EPHA1	RGD	RGD:1304680
Bos taurus	EPHA1	VGNC	VGNC:28532
Canis familiaris	EPHA1	VGNC	VGNC:40404
Felis catus	EPHA1	VGNC	VGNC:61901
Macaca mulatta	EPHA1	VGNC	VGNC:108400
Mus musculus	EPHA1	MGD	MGI:107381
Macaca fascicularis	EPHA1	NCBI
Others	EPHA1	NCBI

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