1. Epigenetics
  2. Epigenetic Reader Domain

(R)-(-)-JQ1 Enantiomer 

Cat. No.: HY-13030A Purity: 99.61%
Data Sheet SDS Handling Instructions

(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.

For research use only. We do not sell to patients.
(R)-(-)-JQ1 Enantiomer Chemical Structure

(R)-(-)-JQ1 Enantiomer Chemical Structure

CAS No. : 1268524-71-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $90 In-stock
50 mg $240 In-stock
100 mg $400 In-stock
200 mg $700 In-stock
500 mg $1500 In-stock
1 g $1800 In-stock
5 g $5000 In-stock
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50 g   Get quote  

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Other Forms of (R)-(-)-JQ1 Enantiomer:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.

IC50 & Target

BET bromodomain[1]

In Vitro

(−)-JQ1 shows no significant interaction with any bromodomain. Besides, (−)-JQ1 enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1].

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.1882 mL 10.9412 mL 21.8823 mL
5 mM 0.4376 mL 2.1882 mL 4.3765 mL
10 mM 0.2188 mL 1.0941 mL 2.1882 mL
References
Molecular Weight

456.99

Formula

C₂₃H₂₅ClN₄O₂S

CAS No.

1268524-71-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.61%

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Product Name:
(R)-(-)-JQ1 Enantiomer
Cat. No.:
HY-13030A
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