1. Epigenetics
  2. Epigenetic Reader Domain
  3. (R)-(-)-JQ1 Enantiomer

(R)-(-)-JQ1 Enantiomer 

Cat. No.: HY-13030A Purity: 99.66%
Handling Instructions

(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.

For research use only. We do not sell to patients.

(R)-(-)-JQ1 Enantiomer Chemical Structure

(R)-(-)-JQ1 Enantiomer Chemical Structure

CAS No. : 1268524-71-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
2 mg USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
50 mg USD 864 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of (R)-(-)-JQ1 Enantiomer:

Top Publications Citing Use of Products

    (R)-(-)-JQ1 Enantiomer purchased from MCE. Usage Cited in: EMBO Mol Med. 2018 Apr;10(4). pii: e8163.

    Western blot analysis of MYC and FGFR3 expression in lysates from MGH-U3 and RT112 cells treated with (+)-JQ1 (1 or 4 μM) for 48 h. Anti-actin antibody is used as a loading control. Pan-FGFR inhibitor, PD173074 (50 nM and 1 μM), and inactive enantiomer (-)-JQ1 (4 μM) are used as controls.

    (R)-(-)-JQ1 Enantiomer purchased from MCE. Usage Cited in: Sci Rep. 2018 Aug 1;8(1):11554.

    A549 cells are mock-treated (0.1% DMSO in culture medium) or treated with RVX-208 at 500 nM, PFI-1 at 500 nM, JQ1 at 300 nM, or with 300 nM (-)-JQ1, an inactive enantiomer of JQ1. The cells are then infected with Ad2 at 1 PFU/cell for 24 h. Viral hexon and penton base (PB) protein is detected by immunoblotting analysis.

    (R)-(-)-JQ1 Enantiomer purchased from MCE. Usage Cited in: J Mol Cell Cardiol. 2018 Dec 7;127:83-96.

    The expression of EndMT-related proteins, VE-cadherin, CD31, vimentin, α-SMA and FSP1, were compared among Ctrl, JQ1(-), JQ1, TGF-β1, and TGF-β1+JQ1 groups in both HUVECs and MAECs.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    (R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.

    IC50 & Target

    BET bromodomain[1]

    In Vitro

    (R)-(-)-JQ1 Enantiomer shows no significant interaction with any bromodomain. Besides, (R)-(-)-JQ1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    456.99

    Formula

    C₂₃H₂₅ClN₄O₂S

    CAS No.

    1268524-71-5

    SMILES

    O=C(C[[email protected]]1N=C(C2=C(N3C1=NN=C3C)SC(C)=C2C)C4=CC=C(C=C4)Cl)OC(C)(C)C

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (218.82 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1882 mL 10.9412 mL 21.8823 mL
    5 mM 0.4376 mL 2.1882 mL 4.3765 mL
    10 mM 0.2188 mL 1.0941 mL 2.1882 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.75 mg/mL (6.02 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.75 mg/mL (6.02 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.75 mg/mL (6.02 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.66%

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    Keywords:

    (R)-(-)-JQ1 EnantiomerEpigenetic Reader DomainInhibitorinhibitorinhibit

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    Product Name:
    (R)-(-)-JQ1 Enantiomer
    Cat. No.:
    HY-13030A
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