1. Epigenetics
  2. Epigenetic Reader Domain

(R)-(-)-JQ1 Enantiomer 

Cat. No.: HY-13030A Purity: 99.61%
Handling Instructions

(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.

For research use only. We do not sell to patients.
(R)-(-)-JQ1 Enantiomer Chemical Structure

(R)-(-)-JQ1 Enantiomer Chemical Structure

CAS No. : 1268524-71-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 158 In-stock
5 mg USD 144 In-stock
10 mg USD 252 In-stock
50 mg USD 864 In-stock
100 mg USD 1440 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of (R)-(-)-JQ1 Enantiomer:

    (R)-(-)-JQ1 Enantiomer purchased from MCE. Usage Cited in: EMBO Mol Med. 2018 Feb 20. pii: e8163.

    Western blot analysis of MYC and FGFR3 expression in lysates from MGH-U3 and RT112 cells treated with (+)-JQ1 (1 or 4 μM) for 48 h. Anti-actin antibody is used as a loading control. Pan-FGFR inhibitor, PD173074 (50 nM and 1 μM), and inactive enantiomer (-)-JQ1 (4 μM) are used as controls.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    (-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.

    IC50 & Target

    BET bromodomain[1]

    In Vitro

    (−)-JQ1 shows no significant interaction with any bromodomain. Besides, (−)-JQ1 enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1].

    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.1882 mL 10.9412 mL 21.8823 mL
    5 mM 0.4376 mL 2.1882 mL 4.3765 mL
    10 mM 0.2188 mL 1.0941 mL 2.1882 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    456.99

    Formula

    C₂₃H₂₅ClN₄O₂S

    CAS No.

    1268524-71-5

    SMILES

    O=C(C[[email protected]]1N=C(C2=C(N3C1=NN=C3C)SC(C)=C2C)C4=CC=C(C=C4)Cl)OC(C)(C)C

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    (−)-JQ1 is prepared in vehicle (10% DMSO, 90% 10% 2-hydroxypropyl β-cyclodextrin)[2].

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

    References

    Purity: 99.61%

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    Product Name:
    (R)-(-)-JQ1 Enantiomer
    Cat. No.:
    HY-13030A
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