1. GPCR/G Protein
    Immunology/Inflammation
    PROTAC
  2. CCR
    Ligand for Target Protein for PROTAC
  3. CCR7 Ligand 1

CCR7 Ligand 1 (Synonyms: CCR7-Cmp2105)

Cat. No.: HY-133073 Purity: 99.64% ee.: 99.94%
Handling Instructions

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.

For research use only. We do not sell to patients.

CCR7 Ligand 1 Chemical Structure

CCR7 Ligand 1 Chemical Structure

CAS No. : 681514-83-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 623 In-stock
Estimated Time of Arrival: December 31
5 mg USD 595 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].

IC50 & Target[1]

Human CCR7

3 nM (Kd)

In Vitro

CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8[1].
CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM[1].
CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7[1].

Molecular Weight

475.56

Formula

C₂₂H₂₉N₅O₅S

CAS No.

681514-83-0

SMILES

O=C(N(C)C)C1=C(C)C=CC(NC(C(N[[email protected]@H](C2=CC=C(C)O2)C(C)(C)C)=N3)=NS3(=O)=O)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (26.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1028 mL 10.5139 mL 21.0278 mL
5 mM 0.4206 mL 2.1028 mL 4.2056 mL
10 mM 0.2103 mL 1.0514 mL 2.1028 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CCR7 Ligand 1CCR7-Cmp2105CCRLigand for Target Protein for PROTACCC chemokine receptorTarget Protein-binding MoietyallostericLigandCCchemokinereceptor7thiadiazole-dioxideliganCCL19Inhibitorinhibitorinhibit

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CCR7 Ligand 1
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HY-133073
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