2. PROTAC Cell Cycle/DNA Damage
  3. Ligands for Target Protein for PROTAC SWI/SNF Complex
  4. SMARCA2/4-ligand-8

SMARCA2/4-ligand-8 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4-degrader-26 (HY-162815).

For research use only. We do not sell to patients.

SMARCA2/4-ligand-8

SMARCA2/4-ligand-8 Chemical Structure

CAS No. : 2380272-41-1

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SMARCA2/4-ligand-8 Related Antibodies

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SMARCA2 SMARCA4 Protein Polybromo-1

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Description

SMARCA2/4-ligand-8 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4-degrader-26 (HY-162815)[1].

IC50 & Target[1]

SMARCA2

 

SMARCA4

 

Molecular Weight

329.35

Formula

C16H19N5O3
CAS No.
SMILES

O=C(O)CN1CCN(C2=CC(C3=CC=CC=C3O)=NN=C2N)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (37.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0363 mL 15.1814 mL 30.3628 mL
5 mM 0.6073 mL 3.0363 mL 6.0726 mL
View the Complete Stock Solution Preparation Table

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0363 mL 15.1814 mL 30.3628 mL 75.9071 mL
5 mM 0.6073 mL 3.0363 mL 6.0726 mL 15.1814 mL
10 mM 0.3036 mL 1.5181 mL 3.0363 mL 7.5907 mL
15 mM 0.2024 mL 1.0121 mL 2.0242 mL 5.0605 mL
20 mM 0.1518 mL 0.7591 mL 1.5181 mL 3.7954 mL
25 mM 0.1215 mL 0.6073 mL 1.2145 mL 3.0363 mL
30 mM 0.1012 mL 0.5060 mL 1.0121 mL 2.5302 mL
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SMARCA2/4-ligand-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMARCA2/4-ligand-82380272-41-1Ligands for Target Protein for PROTACSWI/SNF ComplexTarget Protein-binding MoietySWI/SNF Family of Chromatin-Remodelling ComplexesInhibitorinhibitorinhibit

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