1. PROTAC Epigenetics
  2. Epigenetic Reader Domain PROTACs
  3. PROTAC SMARCA2/4-degrader-26

PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting SMARCA2/4. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid (HY-46618), E3 ligase (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248), and PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845).

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PROTAC SMARCA2/4-degrader-26 Chemical Structure

PROTAC SMARCA2/4-degrader-26 Chemical Structure

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Description

PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting SMARCA2/4. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid (HY-46618), E3 ligase (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248), and PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845)[1].

IC50 & Target

SMARCA2/4[1]

Molecular Weight

741.90

Formula

C38H47N9O5S

SMILES

O=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC(C4=CC=CC=C4O)=NN=C3N)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PROTAC SMARCA2/4-degrader-26
Cat. No.:
HY-162815
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