2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. Ligands for Target Protein for PROTAC HDAC
  4. HDAC4 ligand-2

HDAC4 ligand-2 is a HDAC4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC HDAC4 Degrader-2 (HY-184524).

For research use only. We do not sell to patients.

HDAC4 ligand-2

HDAC4 ligand-2 Chemical Structure

CAS No. : 340736-76-7

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HDAC4 ligand-2 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC4 ligand-2 is a HDAC4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC HDAC4 Degrader-2 (HY-184524)[1].

IC50 & Target[1]

HDAC4

 

Cellular Effect
Cell Line Type Value Description References
MT2 CC50
82.25 μM
Compound: B10
Cytotoxicity against human MT2 cells after 4 days by XTT assay
Cytotoxicity against human MT2 cells after 4 days by XTT assay
[PMID: 19053778]
MT2 EC50
3.06 μM
Compound: B10
Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA
Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA
[PMID: 19053778]
Molecular Weight

258.15

Formula

C10H5F3N2O3
CAS No.
SMILES

O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC4 ligand-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC4 ligand-2340736-76-7Ligands for Target Protein for PROTACHDACTarget Protein-binding MoietyHistone deacetylasesInhibitorinhibitorinhibit

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