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Cat. No.: HY-W039803

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HDAC4 ligand-2

Name: HDAC4 ligand-2
Brand: MedChemExpress
SKU: HY-W039803
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

HDAC4 ligand-2 is a HDAC4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC HDAC4 Degrader-2 (HY-184524).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 340736-76-7
화학식: C₁₀H₅F₃N₂O₃
분자량:258.15

보관:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

HDAC4 ligand-2 Chemical Structure

CAS No.: 340736-76-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HDAC4 ligand-2 is a HDAC4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC HDAC4 Degrader-2 (HY-184524)^[1].

IC₅₀ & Target

^[1]

HDAC4

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	CC₅₀	82.25 μM Compound: B10	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 19053778]
MT2	EC₅₀	3.06 μM Compound: B10	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA	[PMID: 19053778]

Chemical Information

CAS No. 340736-76-7
Appearance Solid
분자량 258.15
화학식 C₁₀H₅F₃N₂O₃
SMILES

O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)O
선적

Room temperature in continental US; may vary elsewhere.

보관

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

순도&문서

Handling Instructions (2659 KB)

References

[1]. Macabuag N, et al. Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology. J Med Chem. 2022 Sep 22;65(18):12445-12459. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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HDAC4 ligand-2

All HDAC Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HDAC4 ligand-2 Related Classifications

HY-W039803 Related Classifications

Bioz

Keywords

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