1. JAK/STAT Signaling
    Stem Cell/Wnt
    PROTAC
  2. STAT
    Ligand for Target Protein for PROTAC
  3. SI-109

SI-109 

Cat. No.: HY-129603
Handling Instructions

SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.

For research use only. We do not sell to patients.

SI-109 Chemical Structure

SI-109 Chemical Structure

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Description

SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36[1].

IC50 & Target[1]

STAT3

9 nM (Ki)

In Vitro

SI-109 exerts a moderate growth inhibitory activity in MOLM-16 cells (IC50=3 μM)[1].
SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM[1].

Molecular Weight

835.79

Formula

C₄₀H₄₄F₂N₇O₉P

SMILES

O=C([[email protected]@H](NC([[email protected]@H]1CC[[email protected]](CCN(C(C)=O)C[[email protected]@H]2NC(C3=CC(C=C(C(F)(P(O)(O)=O)F)C=C4)=C4N3)=O)N1C2=O)=O)CCC(N)=O)NC(C5=CC=CC=C5)C6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SI-109SI109SI 109STATLigand for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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SI-109
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HY-129603
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