2. PROTAC
  3. PROTACs
  4. MI-389

MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase.

For research use only. We do not sell to patients.

MI-389 Chemical Structure

MI-389 Chemical Structure

CAS No. : 2222635-92-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 519 In-stock
Solution
10 mM * 1 mL in DMSO USD 519 In-stock
Solid
5 mg USD 360 In-stock
10 mg USD 580 In-stock
25 mg USD 1160 In-stock
50 mg USD 1860 In-stock
100 mg USD 2980 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

MI-389 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4CRBN E3 ligase[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

654.69

Formula

C35H35FN6O6
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1C2=C(NCCCCCCNC(C3=C(C)NC(/C=C4C5=CC(F)=CC=C5NC/4=O)=C3C)=O)C=CC=C2C(N1C6C(NC(CC6)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (101.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5274 mL 7.6372 mL 15.2744 mL
5 mM 0.3055 mL 1.5274 mL 3.0549 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5274 mL 7.6372 mL 15.2744 mL 38.1860 mL
5 mM 0.3055 mL 1.5274 mL 3.0549 mL 7.6372 mL
10 mM 0.1527 mL 0.7637 mL 1.5274 mL 3.8186 mL
15 mM 0.1018 mL 0.5091 mL 1.0183 mL 2.5457 mL
20 mM 0.0764 mL 0.3819 mL 0.7637 mL 1.9093 mL
25 mM 0.0611 mL 0.3055 mL 0.6110 mL 1.5274 mL
30 mM 0.0509 mL 0.2546 mL 0.5091 mL 1.2729 mL
40 mM 0.0382 mL 0.1909 mL 0.3819 mL 0.9547 mL
50 mM 0.0305 mL 0.1527 mL 0.3055 mL 0.7637 mL
60 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6364 mL
80 mM 0.0191 mL 0.0955 mL 0.1909 mL 0.4773 mL
100 mM 0.0153 mL 0.0764 mL 0.1527 mL 0.3819 mL
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MI-389 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI-3892222635-92-7MI389MI 389PROTACsPROTACtranslation termination factorGSPT1CRL4CRBNInhibitorinhibitorinhibit

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