53902-12-8
Chemical Structure
Tranilast
Synonym(s): MK-341; SB 252218
- CAS No.: 53902-12-8
- Formula:C18H17NO5
- Molecular Weight:327.33
IUPAC Name: (E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoic acid
InChIKey: NZHGWWWHIYHZNX-CSKARUKUSA-N
SMILES: O=C(O)C1=CC=CC=C1NC(/C=C/C2=CC=C(OC)C(OC)=C2)=O
Biological Activity: Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects[1]. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tranilast | 99.95% | Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells. | ||||||||||||||||||||
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Tranilast (Standard) | ≥98% | Tranilast (Standard) is the analytical standard of Tranilast. This product is intended for research and analytical applications. Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells. | ||||||||||||||||||||
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- [1]. K Ikai , et al. Inhibitory Effect of Tranilast on Prostaglandin D Synthetase. Biochem Pharmacol. 1989 Aug 15;38(16):2673-6. [Content Brief]
- [2]. K Miyazawa , et al. Tranilast Antagonizes Angiotensin II and Inhibits Its Biological Effects in Vascular Smooth Muscle Cells. Atherosclerosis. 1996 Apr 5;121(2):167-73. [Content Brief]
Keywords
