2. GPCR/G Protein
  3. Orphan GPCR Angiotensin Receptor
  4. AAA

AAA is an orally active 20-HETE receptor antagonist. AAA exerts antihypertensive and organoprotective effects. AAA blocks 20-HETE prohypertensive actions, suppresses intrarenal and circulating angiotensin II levels, and interferes with renin-angiotensin system interactions. AAA attenuates development of, and reverses established, ANG II (HY-13948)-dependent malignant hypertension. AAA reduces albuminuria, glomerulosclerosis, and cardiac hypertrophy linked to malignant hypertension. AAA can be used for the research of malignant hypertension.

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AAA

AAA Chemical Structure

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500 μg In-stock
1 mg In-stock
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10 mg   Get quote  

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Description

AAA is an orally active 20-HETE receptor antagonist. AAA exerts antihypertensive and organoprotective effects. AAA blocks 20-HETE prohypertensive actions, suppresses intrarenal and circulating angiotensin II levels, and interferes with renin-angiotensin system interactions. AAA attenuates development of, and reverses established, ANG II (HY-13948)-dependent malignant hypertension. AAA reduces albuminuria, glomerulosclerosis, and cardiac hypertrophy linked to malignant hypertension. AAA can be used for the research of malignant hypertension[1].

In Vivo

AAA (10 mg/kg; p.o.; in water; daily; 12 days) attenuates and reverses the development of ANG II (HY-13948)-dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats, reduces associated renal and cardiac injury, and suppresses elevated intrarenal ANG II levels and plasma ACE activity[1].
AAA (10 mg/kg; p.o.; in water; daily; 3 days) rapidly restores impaired renal hemodynamics and vascular responsiveness in Cyp1a1-Ren-2 transgenic rats with established malignant hypertension[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cyp1a1-Ren-2 transgenic (male; malignant hypertension model induced by 0.3% indole-3-carbinol dietary administration)[1]
Dosage: 10 mg/kg per day
Administration: P.o.; daily; 12 days
Result: Reduced SBP elevation to 161 ± 3 mmHg (vs. 199 ± 3 mmHg in untreated I3C-induced rats).
Attenuated albuminuria, glomerulosclerosis index, and cardiac hypertrophy.
Lowered elevated kidney ANG II levels from 405 ± 14 fmol/g to 72 ± 6 fmol/g.
Prevented body weight loss, hunched posture, piloerection, and polydipsia associated with untreated malignant hypertension.
Molecular Weight

483.55

Formula

C24H39NNa2O6
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](NC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O)CC(O[Na])=O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (206.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0680 mL 10.3402 mL 20.6804 mL
5 mM 0.4136 mL 2.0680 mL 4.1361 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 1 mg/mL (2.07 mM); Clear solution; Need ultrasonic and warming

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.52%

SDS (252 KB)

COA (248 KB) HNMR (258 KB) RP-HPLC (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0680 mL 10.3402 mL 20.6804 mL 51.7010 mL
5 mM 0.4136 mL 2.0680 mL 4.1361 mL 10.3402 mL
10 mM 0.2068 mL 1.0340 mL 2.0680 mL 5.1701 mL
15 mM 0.1379 mL 0.6893 mL 1.3787 mL 3.4467 mL
20 mM 0.1034 mL 0.5170 mL 1.0340 mL 2.5850 mL
25 mM 0.0827 mL 0.4136 mL 0.8272 mL 2.0680 mL
30 mM 0.0689 mL 0.3447 mL 0.6893 mL 1.7234 mL
40 mM 0.0517 mL 0.2585 mL 0.5170 mL 1.2925 mL
50 mM 0.0414 mL 0.2068 mL 0.4136 mL 1.0340 mL
60 mM 0.0345 mL 0.1723 mL 0.3447 mL 0.8617 mL
80 mM 0.0259 mL 0.1293 mL 0.2585 mL 0.6463 mL
100 mM 0.0207 mL 0.1034 mL 0.2068 mL 0.5170 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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AAA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AAAOrphan GPCRAngiotensin ReceptorRrphan G protein-coupled receptorcardiac hypertrophy20-HETE receptorglomerulosclerosisrenal hemodynamicsmalignant hypertensionCyp1a1-Ren-2 transgenic ratsalbuminuriaangiotensin IIrenin-angiotensin systemvascular responsivenessInhibitorinhibitorinhibit

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