1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Nitrosoglutathione

Nitrosoglutathione (Synonyms: GSNO; RVC-588; S-Nitroso-L-glutathione)

Cat. No.: HY-D0845
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Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses.

For research use only. We do not sell to patients.

Nitrosoglutathione Chemical Structure

Nitrosoglutathione Chemical Structure

CAS No. : 57564-91-7

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Description

Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].

In Vitro

Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20[3].
Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, but up-regulates endothelial NOS expression in the flap vessels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Lewis rats[4].
Dosage: 0.2 and 0.6 mg/kg.
Administration: Slow intravenous injection via the opposite femoral vein into each rat.
Result: Animals treated with 0.2 mg of GSNO per kilogram before reperfusion had an intermediate survival rate (40.2 ± 4.9%). Although 0.6 mg/kg of GSNO showed a better rescuing effect than 150 mg/kg of NAC, there was no significant difference between the groups.
Molecular Weight

336.32

Formula

C₁₀H₁₆N₄O₇S

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Nitrosoglutathione
Cat. No.:
HY-D0845
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