Based on 1 publication(s) in Google Scholar
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect.
For research use only. We do not sell to patients.
- CAS No.: 129830-38-2
- Formula: C14H23Cl2N3O
- Molecular Weight:320.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Y-27632 dihydrochloride (GMP)
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Biological Activity
Y-27632 dihydrochloride (GMP) (2 μM; 4-8 d) enhances the survival rate and inreases reprogramming of mouse fibroblasts directly converted into neuronal cells[1]. Y-27632 dihydrochloride (GMP) induces human fibroblasts convert into functional cardiomyocytes[2]. Y-27632 dihydrochloride (GMP) induces fibroblasts convert into pluripotent stem cells (hiPSCs)[2]. Y-27632 dihydrochloride (GMP) (2-10 μM) promotes human EPS cell proliferation and induces primed hPSCs convert into hEPS cells[3]. Y-27632 dihydrochloride (GMP) (10 μM) induces human EPS cell derivated from blastocysts[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 129830-38-2
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Appearance Solid
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Molecular Weight 320.26
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Formula C14H23Cl2N3O
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Color White to off-white
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SMILES
O=C([C@@H]1CC[C@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2.[H]Cl.[H]Cl
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Dev Cell
STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma. [Abstract]2025 Jun 23;60(12):1751-1767.e9. PMID: 39933531
Solvent & Solubility
H2O : 100 mg/mL (312.25 mM; Need ultrasonic)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Li X, et al. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015 Aug 6;17(2):195-203. [Content Brief]
[2]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20. [Content Brief]
[3]. Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016 Jun 7;15(10):2301-2312. [Content Brief]
[4]. Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017 Apr 6;169(2):243-257.e25. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.1225 mL | 15.6123 mL | 31.2246 mL | 78.0616 mL |
| 5 mM | 0.6245 mL | 3.1225 mL | 6.2449 mL | 15.6123 mL | |
| 10 mM | 0.3122 mL | 1.5612 mL | 3.1225 mL | 7.8062 mL | |
| 15 mM | 0.2082 mL | 1.0408 mL | 2.0816 mL | 5.2041 mL | |
| 20 mM | 0.1561 mL | 0.7806 mL | 1.5612 mL | 3.9031 mL | |
| 25 mM | 0.1249 mL | 0.6245 mL | 1.2490 mL | 3.1225 mL | |
| 30 mM | 0.1041 mL | 0.5204 mL | 1.0408 mL | 2.6021 mL | |
| 40 mM | 0.0781 mL | 0.3903 mL | 0.7806 mL | 1.9515 mL | |
| 50 mM | 0.0624 mL | 0.3122 mL | 0.6245 mL | 1.5612 mL | |
| 60 mM | 0.0520 mL | 0.2602 mL | 0.5204 mL | 1.3010 mL | |
| 80 mM | 0.0390 mL | 0.1952 mL | 0.3903 mL | 0.9758 mL | |
| 100 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7806 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Y-27632 dihydrochloride (GMP) Related Classifications
HY-10583G Related Classifications
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