ROCK
Rho-associated protein kinase; Rho-associated kinase; Rho-kinase; ROK
ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. ROCKs (ROCK1 and ROCK2) occur in mammals, zebrafish, Xenopus, invertebrates and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ROCK consists of a kinase domain, acoiled-coil region and a Pleckstrin homology (PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present. ROCK plays a role in a wide range of different cellular phenomena, as ROCK is a downstream effector protein of the small GTPase Rho, which is one of the major regulators of the cytoskeleton.
ROCK Isoform Specific Products
All Product Categories
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ROCK Related Products (200)
Related Products (200)
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Antibodies (12)
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ROCK Isoform Comparison
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GSK429286A (Standard)
0 ImagesCat. No.: HY-11000RCAS No.: 864082-47-3GSK429286A (Standard) is the analytical standard of GSK429286A (HY-11000). This product is intended for research and analytical applications. GSK429286A is a selective inhibitor of ROCK1 with an IC50 value of 14 nM.
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8-iso Prostaglandin F1β
0 ImagesCat. No.: HY-130448CAS No.: 26771-95-98-iso Prostaglandin F1β is an isoprostane, that exhibits vasoconstrictive effect in neonatal porcine pulmonary arteries, pulmonary veins, and mesenteric arteries. 8-iso Prostaglandin F1β targets TXA2 receptor and exhibits the blood vessel contractile efficacy under the influence of tyrosine kinase and Rho kinase.
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Y-30141
0 ImagesCat. No.: HY-183451CAS No.: 199433-55-1Y-30141 is a hinge-binding 7-azaindole-based Rho kinase (ROCK) inhibitor. Y-30141 can be used for the research of hypertension.
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HA-100 (Standard)
0 ImagesCat. No.: HY-100984RCAS No.: 84468-24-6HA-100 (Standard) is the analytical standard of HA-100 (HY-100984). This product is intended for research and analytical applications. HA-100 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor.
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BAY-549 (Standard)
0 ImagesCat. No.: HY-10319RCAS No.: 867017-68-3Synonyms: ROCK-IN-2 (Standard); Azaindole 1 (Standard); TC-S 7001 (Standard)BAY-549 (Standard) is the analytical standard of BAY-549 (HY-10319). This product is intended for research and analytical applications. BAY-549 (Azaindole 1), a chemical probe, is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2, respectively.
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Hydroxyfasudil (Standard)
0 ImagesCat. No.: HY-13911RCAS No.: 105628-72-6Synonyms: HA-1100 (Standard)Hydroxyfasudil (Standard) is the analytical standard of Hydroxyfasudil. This product is intended for research and analytical applications. Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.
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Belumosudil (Standard)
0 ImagesSynonyms: KD025 (Standard); SLx-2119 (Standard)
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ROCK-IN-18
0 ImagesCat. No.: HY-188017CAS No.: 3060895-25-9ROCK-IN-18 is a blood-brain barrier-permeable selective inhibitor of the ROCK2 protein kinase. ROCK-IN-18 is applicable to research related to cardiovascular diseases, neurological diseases, breast cancer, colon cancer, pancreatic cancer and other disorders.
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Y-27632 (Standard)
0 ImagesY-27632 (Standard) is the analytical standard of Y-27632 (HY-10071). This product is intended for research and analytical applications. Y-27632 is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade.
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ROCK-IN-13
0 ImagesCat. No.: HY-116233CAS No.: 1219727-16-8ROCK-IN-13 is a ROCK2 inhibitor with an IC50 of 8 nM against human ROCK2. ROCK-IN-13 has the potential for use in the research of diseases such as multiple sclerosis, glaucoma, and cardiovascular diseases.
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Cinnamyl Alcohol-d9
0 ImagesCat. No.: HY-Y0078S1CAS No.: 3028869-57-7
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Cinnamyl Alcohol (Standard)
0 ImagesCinnamyl Alcohol (Standard) is the analytical standard of Cinnamyl Alcohole (HY-Y0078). This product is intended for research and analytical applications. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.
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Sovesudil hydrochloride (Standard)
0 ImagesCat. No.: HY-109191ARCAS No.: 2984963-50-8Synonyms: PHP-201 hydrochloride (Standard); AMA0076 hydrochloride (Standard)Sovesudil hydrochloride (Standard) is the analytical standard of Sovesudil (hydrochloride) (HY-109191A). This product is intended for research and analytical applications. Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho Kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia.
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Nocarnickelamide B
0 ImagesCat. No.: HY-N15301Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC50s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch.
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Ripasudil (Standard)
0 ImagesSynonyms: K-115 (Standard)
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LX7101 monohydrochloride
0 ImagesCat. No.: HY-12659BCAS No.: 2319882-48-7LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research.
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Y-33075 dihydrochloride (Standard)
0 ImagesCat. No.: HY-10069RCAS No.: 173897-44-4Y-33075 (dihydrochloride) (Standard) is the analytical standard of Y-33075 (dihydrochloride) (HY-10069). This product is intended for research and analytical applications. Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.
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Y-33075 (Standard)
0 ImagesCat. No.: HY-10067RCAS No.: 199433-58-4Synonyms: Y-39983 free base (Standard)Y-33075 (Standard) is the analytical standard of Y-33075 (HY-10067). This product is intended for research and analytical applications. Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
