LX7101 monohydrochloride
Based on 3 publication(s) in Google Scholar
LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research.
For research use only. We do not sell to patients.
- CAS No.: 2319882-48-7
- Formula: C23H30ClN7O3
- Molecular Weight:487.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LX7101 monohydrochloride
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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WB
Biological Activity
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LIMK1 24 nM (IC50) |
LIMK2 1.6 nM (IC50) |
ROCK2 10 nM (IC50) |
PKA <1 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2319882-48-7
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Molecular Weight 487.98
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Formula C23H30ClN7O3
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SMILES
NCC1(C(NC2=CC(OC(N(C)C)=O)=CC=C2)=O)CCN(C3=C4C(NC=C4C)=NC=N3)CC1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Oncogene
LIMK2 promotes melanoma tumor growth and metastasis through G3BP1-ESM1 pathway-mediated apoptosis inhibition. [Abstract]2023 May;42(18):1478-1491. PMID: 36922679
LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 May;42(18):1478-1491. [Abstract]
Both LX7101 (5 μM) and TH-257 (5 μM) inhibits the colony-forming ability of melanoma cells (A375-MA2, MeWo, and SK-MEL-147 cells) in soft-agar.
LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 May;42(18):1478-1491. [Abstract]
Both LX7101 (5 μM; 24 h) and TH-257 (5 μM; 24 h) reduces the phosphorylation of G3BP1 in A375-MA2 and SK-MEL-147 cells.
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Sci Rep
Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells. [Abstract]2018 Aug 2;8(1):11585. PMID: 30072797
LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Aug 2;8(1):11585. [Abstract]
Western blot analysis of GFAP protein levels in LX7101 and DMSO-treated iNPC-KO lines. GAPDH is used as a loading control.
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Purity & Documentation
References
[1]. Boland S, et al. Design, synthesis and biological characterization of selective LIMK inhibitors. Bioorganic & Medicinal Chemistry Letters (2015), 25(18), 4005-4010. [Content Brief]
[2]. Harrison BA, et al. Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma. ACS Medicinal Chemistry Letters (2015), 6(1), 84-88. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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