ROCK-IN-13
ROCK-IN-13 is a ROCK2 inhibitor with an IC50 of 8 nM against human ROCK2. ROCK-IN-13 has the potential for use in the research of diseases such as multiple sclerosis, glaucoma, and cardiovascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 1219727-16-8
- Formula: C20H22N4O
- Molecular Weight:334.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
ROCK2 8 nM (IC50) |
In Vitro
ROCK-IN-13 (Compound D3) (4 h) potently inhibits recombinant human ROCK2, with an IC50 value of 8 nM[1].
ROCK-IN-13 (70 min) weakly inhibits recombinant human PKA, with an experimental IC50 of 3381 nM, and shows 422-fold higher selectivity for ROCK2 than for PKA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1219727-16-8
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Molecular Weight 334.41
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Formula C20H22N4O
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SMILES
O=C(N(C(C)C)CC1=CC=CC=C1)NC2=CC=C(C=C2)C3=CNN=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ROCK-IN-13 Related Classifications
HY-116233 Related Classifications
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