84468-24-6
84468-24-6
Chemical Structure
HA-100
- CAS No.: 84468-24-6
- Formula:C13H15N3O2S
- Molecular Weight:277.34
IUPAC Name: 5-(piperazin-1-ylsulfonyl)isoquinoline
InChIKey: UPTYCYWTFGTCCG-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O
Biological Activity: HA-100 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HA-100 | 99.87% | HA-100 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor. | ||||||||||||||||||||
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HA-100 (Standard) | ≥98% | HA-100 (Standard) is the analytical standard of HA-100 (HY-100984). This product is intended for research and analytical applications. HA-100 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor. | ||||||||||||||||||||
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References
- [1]. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. [Content Brief]
- [2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557. [Content Brief]
Keywords
