ROCK Inhibitor

ROCK Inhibitors (38):

Cat. No.	Product Name	Effect	Purity

HY-13257

Thiazovivin	Inhibitor	99.94%
Thiazovivin is a potent ROCK inhibitor, which can protect human embryonic stem cells. Thiazovivin improves the efficiency of iPSC generation.

HY-15727

Afuresertib	Inhibitor	99.54%
Afuresertib (GSK2110183) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with K_is of 0.08/2/2.6 nM for Akt1/Akt2/Akt3, respectively.

HY-10067

Y-33075	Inhibitor	99.19%
Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC₅₀ of 3.6 nM.

HY-121750

CCG-222740	Inhibitor	99.85%
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.

HY-10583G

Y-27632 dihydrochloride (GMP)	Inhibitor
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect.

HY-10069

Y-33075 dihydrochloride	Inhibitor	98.02%
Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC₅₀ of 3.6 nM.

HY-148808

Zelasudil	Inhibitor	99.86%
Zelasudil is a Rho-associated (ROCK) kinase inhibitor. Zelasudil has a ROCK2 binding affinity.

HY-15727A

Afuresertib hydrochloride	Inhibitor	99.03%
Afuresertib hydrochloride (GSK 2110183 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with K_is of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively.

HY-Q22471

ROCK1-IN-1	Inhibitor	98.86%
ROCK1-IN-1 is a ROCK1 inhibitor with a K_i value of 540 nM. ROCK1-IN-1 can be used for the research of hypertension, glaucoma and erectile dysfunction.

HY-101244

ZINC00881524	Inhibitor	99.26%
ZINC00881524 is a ROCK inhibitor.

HY-13257G

Thiazovivin (GMP)	Inhibitor
Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor.

HY-137436

Cotosudil	Inhibitor	99.05%
Cotosudil is a ROCK kinase inhibitor, which can be used for glaucoma or ocular hypertension research.

HY-139170

CAY10746	Inhibitor	99.77%
CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC₅₀ values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR).

HY-125639

(rac)-AR-13503	Inhibitor
(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice.

HY-156592A

ROCK2-IN-6 hydrochloride	Inhibitor	99.95%
ROCK2-IN-6 hydrochloride (Comp A) is a selective ROCK2 inhibitor, can be used for ROCK mediated diseases, autoimmune diseases and inflammation research.

HY-112362

3-(4-Pyridyl)indole	Inhibitor	≥99.0%
3-(4-Pyridyl)indole (Rockout) is a Rho-kinase (ROCK) inhibitor, with an IC₅₀ of 25 μM. 3-(4-Pyridyl)indole can inhibit blebbing and cause dissolution of actin stress fibers in a wound healing assay.

HY-108519

AS1892802	Inhibitor	99.33%
AS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain.

HY-111239

GSK317354A	Inhibitor
GSK317354A is a ROCK and GRK inhibitor. GSK317354A can be used for heart failure and Parkinson’s disease research.

HY-100984A

HA-100 hydrochloride	Inhibitor
HA-100 hydrochloride is a potent protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor.

HY-153011

ROCK-IN-5	Inhibitor	≥98.0%
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK, ERK, GSK, and AGC protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research.

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