Based on 1 Customer Validation
Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 1226056-71-8
- Formula: C15H13N5OS
- Molecular Weight:311.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Thiazovivin (GMP) (0.5 μM, 1 day) promotes rapid and efficient reprogramming of mouse tail tip and embryonic fibroblasts into iPSCs[1].
Thiazovivin enhances the efficiency in reprograming endometrial adult stromal cells to iPSCs[2].
Thiazovivin (2 μM) induces iPSCs and induced neural stem cells (iNSCs) from human urine cells (UCs)[3].
Thiazovivin (2 μM, for the first 24 h) improves growth rate of hiPSCs[4].
Thiazovivin (0.5 μM) together with SB431542 and PD0325901 promotes iPSC reprogramming by regulating cell-cell interactions[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1226056-71-8
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Appearance Solid
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Molecular Weight 311.36
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Formula C15H13N5OS
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Color White to yellow
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SMILES
O=C(C1=CSC(NC2=NC=NC=C2)=N1)NCC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Park HS, et al. Generation of induced pluripotent stem cells without genetic defects by small molecules. Biomaterials. 2015 Jan;39:47-58. [Content Brief]
[2]. Mohseni R, et al. Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. Cell Biol Int. 2015 May;39(5):515-8. [Content Brief]
[3]. Cheng L, et al. Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol. Front Mol Neurosci. 2017 Oct 30;10:348. [Content Brief]
[4]. Kuo HH, et al. Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture. Stem Cell Reports. 2020 Feb 11;14(2):256-270. [Content Brief]
[5]. Lin T, et al. A chemical platform for improved induction of human iPSCs. Nat Methods. 2009 Nov;6(11):805-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thiazovivin (GMP) Related Classifications
HY-13257G Related Classifications
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