Thiazovivin 

Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor^[1].

Thiazovivin (GMP) (0.5  μM, at 1 day) promotes rapid and efficient reprogramming of mouse tail tip and embryonic fibroblasts into iPSCs^[1].
Thiazovivin (GMP) enhances the efficiency in reprograming endometrial adult stromal cells to iPSCs^[2].
Thiazovivin (GMP) (2 μM) induces iPSCs and induced neural stem cells (iNSCs) from human urine cells (UCs)^[3].
Thiazovivin (GMP) (2 μM, for the first 24 h) improves growth rate of hiPSCs^[4].
Thiazovivin (GMP) (0.5 μM) together with SB431542 and PD0325901 promotes iPSC reprogramming by regulating cell-cell interactions^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

311.36

C₁₅H₁₃N₅OS

1226056-71-8

Solid

Off-white to light yellow

O=C(C1=CSC(NC2=NC=NC=C2)=N1)NCC3=CC=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Park HS, et al. Generation of induced pluripotent stem cells without genetic defects by small molecules. Biomaterials. 2015 Jan;39:47-58.  [Content Brief]

  [2]. Mohseni R, et al. Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. Cell Biol Int. 2015 May;39(5):515-8.  [Content Brief]

  [3]. Cheng L, et al. Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol. Front Mol Neurosci. 2017 Oct 30;10:348.  [Content Brief]

  [4]. Kuo HH, et al. Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture. Stem Cell Reports. 2020 Feb 11;14(2):256-270.  [Content Brief]

  [5]. Lin T, et al. A chemical platform for improved induction of human iPSCs. Nat Methods. 2009 Nov;6(11):805-8.  [Content Brief]