1922098-69-8
1922098-69-8
Chemical Structure
CCG-222740
- CAS No.: 1922098-69-8
- Formula:C23H19ClF2N2O3
- Molecular Weight:444.86
IUPAC Name: N-(4-chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide
InChIKey: PMTPYUTZAJWGPE-UHFFFAOYSA-N
SMILES: O=C(C1CN(C(C2=CC=CC(C3=CC=CO3)=C2)=O)CC(F)(F)C1)NC4=CC=C(Cl)C=C4
Biological Activity: CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor[1]. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CCG-222740 | 99.53% | CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-108361RCCG-203971 (Standard) -
Similarity Score 0.81
HY-111432CCG-232601 -
Similarity Score 0.73
HY-153078MRTF/SRF-IN-1 -
Similarity Score 0.55
HY-120855CCG-100602 -
Similarity Score 0.51
HY-150700RLX-33 -
Similarity Score 0.50
HY-187010PAI-1-IN-2 -
Similarity Score 0.49
HY-13454CID 2011756 -
Similarity Score 0.49
HY-147558CB1R Allosteric modulator 1 -
Similarity Score 0.49
HY-123807JNJ-5234801 -
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References
- [1]. Leal AS, et al. The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice. Sci Rep. 2019 May 8;9(1):7072. [Content Brief]
- [2]. Yu-Wai-Man C, et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis. Sci Rep. 2017 Mar 31;7(1):518. [Content Brief]
