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Cat. No.: HY-187010

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PAI-1-IN-2

PAI-1-IN-2 is a PAI-1 inhibitor with an IC₅₀ of 7.45 μM. By inhibiting PAI-1, PAI-1-IN-2 relieves the inhibitory effect of PAI-1 on tPA and uPA, thereby increasing plasmin levels and promoting fibrinolysis. PAI-1-IN-2 can be used in research related to cardiovascular diseases and cancers.

For research use only. We do not sell to patients.

CAS No.: 1190221-46-5
Formula: C₂₁H₁₇ClN₂O₆
Molecular Weight:428.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PAI-1-IN-2 Chemical Structure

CAS No.: 1190221-46-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

PAI-1

7.45 μM (IC₅₀)

In Vitro

PAI-1-IN-2 (compound 52) at concentrations of 20-50 μM results in residual PAI-1 activities of 17.7% and 59.2%, respectively, in a cell-free pure enzyme system, with an IC₅₀ value of 7.45 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2
Rat^[1]	5 mg/kg	p.o.	14 μM	2 h	2.7 h

Chemical Information

CAS No. 1190221-46-5
Molecular Weight 428.83
Formula C₂₁H₁₇ClN₂O₆
SMILES

O=C(O)C1=CC(Cl)=CC=C1NC(=O)COCC(=O)NC2=CC=CC(=C2)C=3OC=CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yamaoka N, et al. Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives. Bioorganic & medicinal chemistry letters. 2018 Feb 15;28(4):809-813. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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