PAI-1-IN-2
PAI-1-IN-2 is a PAI-1 inhibitor with an IC50 of 7.45 μM. By inhibiting PAI-1, PAI-1-IN-2 relieves the inhibitory effect of PAI-1 on tPA and uPA, thereby increasing plasmin levels and promoting fibrinolysis. PAI-1-IN-2 can be used in research related to cardiovascular diseases and cancers.
For research use only. We do not sell to patients.
- CAS No.: 1190221-46-5
- Formula: C21H17ClN2O6
- Molecular Weight:428.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PAI-1 7.45 μM (IC50) |
PAI-1-IN-2 (compound 52) at concentrations of 20-50 μM results in residual PAI-1 activities of 17.7% and 59.2%, respectively, in a cell-free pure enzyme system, with an IC50 value of 7.45 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | Tmax | T1/2 |
|---|---|---|---|---|---|
| Rat[1] | 5 mg/kg | p.o. | 14 μM | 2 h | 2.7 h |
Chemical Information
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CAS No. 1190221-46-5
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Molecular Weight 428.83
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Formula C21H17ClN2O6
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SMILES
O=C(O)C1=CC(Cl)=CC=C1NC(=O)COCC(=O)NC2=CC=CC(=C2)C=3OC=CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAI-1-IN-2 Related Classifications
HY-187010 Related Classifications
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