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Cat. No.: HY-187010

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PAI-1-IN-2

PAI-1-IN-2 is a PAI-1 inhibitor with an IC₅₀ of 7.45 μM. By inhibiting PAI-1, PAI-1-IN-2 relieves the inhibitory effect of PAI-1 on tPA and uPA, thereby increasing plasmin levels and promoting fibrinolysis. PAI-1-IN-2 can be used in research related to cardiovascular diseases and cancers.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1190221-46-5
Formule: C₂₁H₁₇ClN₂O₆
Masse moléculaire:428.83

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PAI-1-IN-2 Chemical Structure

CAS No.: 1190221-46-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

PAI-1

7.45 μM (IC₅₀)

In Vitro

PAI-1-IN-2 (compound 52) at concentrations of 20-50 μM results in residual PAI-1 activities of 17.7% and 59.2%, respectively, in a cell-free pure enzyme system, with an IC₅₀ value of 7.45 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2
Rat^[1]	5 mg/kg	p.o.	14 μM	2 h	2.7 h

Chemical Information

CAS No. 1190221-46-5
Masse moléculaire 428.83
Formule C₂₁H₁₇ClN₂O₆
SMILES

O=C(O)C1=CC(Cl)=CC=C1NC(=O)COCC(=O)NC2=CC=CC(=C2)C=3OC=CC3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yamaoka N, et al. Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives. Bioorganic & medicinal chemistry letters. 2018 Feb 15;28(4):809-813. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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