1. GPCR/G Protein
  2. Ras
  3. CCG-232601

CCG-232601 

Cat. No.: HY-111432
Handling Instructions

CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma.

For research use only. We do not sell to patients.

CCG-232601 Chemical Structure

CCG-232601 Chemical Structure

CAS No. : 1922099-21-5

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All Ras Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma[1].

In Vitro

CCG-232601 inhibits SRE.L activity with an IC50 of 0.55 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CCG-232601 (50 mg/kg; i.g.; intracutaneous injections of bleomycin; daily for 14 days) inhibits bleomycin-induced skin fibrosis in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

455.88

Formula

C24H20ClF2N3O2

CAS No.
SMILES

O=C(C1CN(C(C2=CC=CC(C3=CC=NC=C3)=C2)=O)CC(F)(F)C1)NC4=CC=C(Cl)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CCG-232601
Cat. No.:
HY-111432
Quantity:
MCE Japan Authorized Agent: