CCG-232601
Based on 1 Customer Validation
CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 1922099-21-5
- Formula: C24H20ClF2N3O2
- Molecular Weight:455.88
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CCG-232601 inhibits SRE.L activity with an IC50 of 0.55 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1922099-21-5
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Appearance Solid
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Molecular Weight 455.88
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Formula C24H20ClF2N3O2
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Color White to off-white
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SMILES
O=C(C1CN(C(C2=CC=CC(C3=CC=NC=C3)=C2)=O)CC(F)(F)C1)NC4=CC=C(Cl)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 40 mg/mL (87.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1936 mL | 10.9678 mL | 21.9356 mL | 54.8390 mL |
| 5 mM | 0.4387 mL | 2.1936 mL | 4.3871 mL | 10.9678 mL | |
| 10 mM | 0.2194 mL | 1.0968 mL | 2.1936 mL | 5.4839 mL | |
| 15 mM | 0.1462 mL | 0.7312 mL | 1.4624 mL | 3.6559 mL | |
| 20 mM | 0.1097 mL | 0.5484 mL | 1.0968 mL | 2.7419 mL | |
| 25 mM | 0.0877 mL | 0.4387 mL | 0.8774 mL | 2.1936 mL | |
| 30 mM | 0.0731 mL | 0.3656 mL | 0.7312 mL | 1.8280 mL | |
| 40 mM | 0.0548 mL | 0.2742 mL | 0.5484 mL | 1.3710 mL | |
| 50 mM | 0.0439 mL | 0.2194 mL | 0.4387 mL | 1.0968 mL | |
| 60 mM | 0.0366 mL | 0.1828 mL | 0.3656 mL | 0.9140 mL | |
| 80 mM | 0.0274 mL | 0.1371 mL | 0.2742 mL | 0.6855 mL |
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