2444764-03-6
2444764-03-6
Chemical Structure
GKI-1
- CAS. Nr.: 2444764-03-6
- Formula:C15H12ClN3
- Molecular Weight:269.73
IUPAC Name: N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)aniline
InChIKey: GPXJDHFWTOJHQQ-UHFFFAOYSA-N
SMILES: ClC(C=C1)=CC=C1NC2=CC(C3=CNN=C3)=CC=C2
Biological Activity: GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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GKI-1 | 99.96% | GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA. | ||||||||||||||||||||
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GKI-1 (Standard) | ≥98% | GKI-1 (Standard) is the analytical standard of GKI-1 (HY-100521). This product is intended for research and analytical applications. GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA. | ||||||||||||||||||||
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References
Keywords
