911417-87-3
911417-87-3
Chemical Structure
Belumosudil
Synonym(s): KD025; SLx-2119
- CAS No.: 911417-87-3
- Formula:C26H24N6O2
- Molecular Weight:452.51
IUPAC Name: 2-(3-(4-((1H-indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide
InChIKey: GKHIVNAUVKXIIY-UHFFFAOYSA-N
SMILES: O=C(NC(C)C)COC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1
Biological Activity: Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Belumosudil | 99.83% | Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties. | ||||||||||||||||||||
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Belumosudil (Standard) | ≥98% | Belumosudil (Standard) is the analytical standard of Belumosudil. This product is intended for research and analytical applications. Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties. | ||||||||||||||||||||
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Belumosudil-d7 | Belumosudil-d7 (KD025-d7) is deuterium labeled Belumosudil. Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.93
HY-15307ARBelumosudil mesylate (Standard) -
Similarity Score 0.89
HY-164809Desisopropyle-belumosudil -
Similarity Score 0.72
HY-145597KL-11743 -
Similarity Score 0.58
HY-122198ML367 -
Similarity Score 0.57
HY-168086LSD1-IN-35 -
Similarity Score 0.56
HY-169860BCRP-IN-2 -
Similarity Score 0.56
HY-170885Group II intron-IN-1 -
Similarity Score 0.55
HY-163943UNI418 -
Similarity Score 0.55
HY-112392GSK-3 Inhibitor XIII -
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