1. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  2. ROCK
  3. Chroman 1

Chroman 1 

Cat. No.: HY-15392 Purity: 99.48%
COA Handling Instructions

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM.

For research use only. We do not sell to patients.

Chroman 1 Chemical Structure

Chroman 1 Chemical Structure

CAS No. : 1273579-40-0

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 235 In-stock
Solution
10 mM * 1 mL in DMSO USD 235 In-stock
Solid
5 mg USD 210 In-stock
10 mg USD 340 In-stock
50 mg USD 980 In-stock
100 mg USD 1750 In-stock
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Customer Review

Based on 15 publication(s) in Google Scholar

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Description

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM[1][2].

IC50 & Target[1][2]

ROCK2

1 pM (IC50)

ROCK1

52 pM (IC50)

MRCK

150 nM (IC50)

In Vitro

Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: hESCs (human pluripotent stem cells) (WA09)
Concentration: 50 nM
Incubation Time: 0-12 h or 24 h
Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation.

Western Blot Analysis[1]

Cell Line: hESCs (human pluripotent stem cells) (WA09)
Concentration: 50 nM
Incubation Time: 24 h
Result: Partially inhibited caspase-3 activation.
Molecular Weight

436.50

Formula

C24H28N4O4

CAS No.
Appearance

Solid

Color

White to pink

SMILES

O=C([C@@H]1COC2=CC=C(OC)C=C2C1)NC3=CC=C(C4=CNN=C4)C=C3OCCN(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (114.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2910 mL 11.4548 mL 22.9095 mL
5 mM 0.4582 mL 2.2910 mL 4.5819 mL
10 mM 0.2291 mL 1.1455 mL 2.2910 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 3.25 mg/mL (7.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

    Solubility: 2.5 mg/mL (5.73 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Chroman 1
Cat. No.:
HY-15392
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